Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis
Joint Authors
Permpalung, Nitipong
Upala, Sikarin
Sanguankeo, Anawin
Sornprom, Suthanya
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Clostridium difficile infection is a leading cause of nosocomial diarrhea in developed countries.
Studies evaluating the associations of increased risk of community-acquired CDAD and the use of nonsteroidal anti-inflammatory drugs (NSAIDs) have yielded inconclusive results.
We conducted a systematic review and meta-analysis to compare the odds of NSAID exposure in patients with CDAD versus patients without CDAD in both community-based and healthcare-associated settings.
Methods.
Relevant observational studies indexed in PubMed/MEDLINE and EMBASE up to February 2015 were analyzed and data were extracted from nine studies.
Of these, eight studies were included in the meta-analysis.
Results.
A search of the databases resulted in 987 articles.
The nine studies from which data were extracted involved over 39,000 subjects.
The pooled odds ratio for history of NSAID use in participants with CDAD compared with controls was 1.41 (95% CI 1.06–1.87; p < 0.01 ), indicating a significant increased odds of CDAD among patients exposed to NSAIDs.
Conclusions.
To the best of our knowledge, this is the first study of its nature to demonstrate the association between the use of NSAIDs and increased risk of CDAD.
Further studies to evaluate if any specific types of NSAIDs can increase the risk of CDAD are warranted.
American Psychological Association (APA)
Permpalung, Nitipong& Upala, Sikarin& Sanguankeo, Anawin& Sornprom, Suthanya. 2016. Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099919
Modern Language Association (MLA)
Permpalung, Nitipong…[et al.]. Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099919
American Medical Association (AMA)
Permpalung, Nitipong& Upala, Sikarin& Sanguankeo, Anawin& Sornprom, Suthanya. Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099919