A Numerical Simulation of Cell Separation by Simplified Asymmetric Pinched Flow Fractionation

المؤلفون المشاركون

Ma, Jing-Tao
Xu, Yuan-Qing
Tang, Xiao-Ying

المصدر

Computational and Mathematical Methods in Medicine

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-08-15

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

As a typical microfluidic cell sorting technique, the size-dependent cell sorting has attracted much interest in recent years.

In this paper, a size-dependent cell sorting scheme is presented based on a controllable asymmetric pinched flow by employing an immersed boundary-lattice Boltzmann method (IB-LBM).

The geometry of channels consists of 2 upstream branches, 1 transitional channel, and 4 downstream branches (D-branches).

Simulations are conducted by varying inlet flow ratio, the cell size, and the ratio of flux of outlet 4 to the total flux.

It is found that, after being randomly released in one upstream branch, the cells are aligned in a line close to one sidewall of the transitional channel due to the hydrodynamic forces of the asymmetric pinched flow.

Cells with different sizes can be fed into different downstream D-branches just by regulating the flux of one D-branch.

A principle governing D-branch choice of a cell is obtained, with which a series of numerical cases are performed to sort the cell mixture involving two, three, or four classes of diameters.

Results show that, for each case, an adaptive regulating flux can be determined to sort the cell mixture effectively.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ma, Jing-Tao& Xu, Yuan-Qing& Tang, Xiao-Ying. 2016. A Numerical Simulation of Cell Separation by Simplified Asymmetric Pinched Flow Fractionation. Computational and Mathematical Methods in Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1100083

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ma, Jing-Tao…[et al.]. A Numerical Simulation of Cell Separation by Simplified Asymmetric Pinched Flow Fractionation. Computational and Mathematical Methods in Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1100083

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ma, Jing-Tao& Xu, Yuan-Qing& Tang, Xiao-Ying. A Numerical Simulation of Cell Separation by Simplified Asymmetric Pinched Flow Fractionation. Computational and Mathematical Methods in Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1100083

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1100083