A Numerical Simulation of Cell Separation by Simplified Asymmetric Pinched Flow Fractionation
Joint Authors
Ma, Jing-Tao
Xu, Yuan-Qing
Tang, Xiao-Ying
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
As a typical microfluidic cell sorting technique, the size-dependent cell sorting has attracted much interest in recent years.
In this paper, a size-dependent cell sorting scheme is presented based on a controllable asymmetric pinched flow by employing an immersed boundary-lattice Boltzmann method (IB-LBM).
The geometry of channels consists of 2 upstream branches, 1 transitional channel, and 4 downstream branches (D-branches).
Simulations are conducted by varying inlet flow ratio, the cell size, and the ratio of flux of outlet 4 to the total flux.
It is found that, after being randomly released in one upstream branch, the cells are aligned in a line close to one sidewall of the transitional channel due to the hydrodynamic forces of the asymmetric pinched flow.
Cells with different sizes can be fed into different downstream D-branches just by regulating the flux of one D-branch.
A principle governing D-branch choice of a cell is obtained, with which a series of numerical cases are performed to sort the cell mixture involving two, three, or four classes of diameters.
Results show that, for each case, an adaptive regulating flux can be determined to sort the cell mixture effectively.
American Psychological Association (APA)
Ma, Jing-Tao& Xu, Yuan-Qing& Tang, Xiao-Ying. 2016. A Numerical Simulation of Cell Separation by Simplified Asymmetric Pinched Flow Fractionation. Computational and Mathematical Methods in Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1100083
Modern Language Association (MLA)
Ma, Jing-Tao…[et al.]. A Numerical Simulation of Cell Separation by Simplified Asymmetric Pinched Flow Fractionation. Computational and Mathematical Methods in Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1100083
American Medical Association (AMA)
Ma, Jing-Tao& Xu, Yuan-Qing& Tang, Xiao-Ying. A Numerical Simulation of Cell Separation by Simplified Asymmetric Pinched Flow Fractionation. Computational and Mathematical Methods in Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1100083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100083