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A Computational Model for Investigating Tumor Apoptosis Induced by Mesenchymal Stem Cell-Derived Secretome
المؤلفون المشاركون
Hendrata, Melisa
Sudiono, Janti
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-09
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Apoptosis is a programmed cell death that occurs naturally in physiological and pathological conditions.
Defective apoptosis can trigger the development and progression of cancer.
Experiments suggest the ability of secretome derived from mesenchymal stem cells (MSC) to induce apoptosis in cancer cells.
We develop a hybrid discrete-continuous multiscale model to further investigate the effect of MSC-derived secretome in tumor growth.
The model encompasses three biological scales.
At the molecular scale, a system of ordinary differential equations regulate the expression of proteins involved in apoptosis signaling pathways.
At the cellular scale, discrete equations control cellular migration, phenotypic switching, and proliferation.
At the extracellular scale, a system of partial differential equations are employed to describe the dynamics of microenvironmental chemicals concentrations.
The simulation is able to produce both avascular tumor growth rate and phenotypic patterns as observed in the experiments.
In addition, we obtain good quantitative agreements with the experimental data on the apoptosis of HeLa cancer cells treated with MSC-derived secretome.
We use this model to predict the growth of avascular tumor under various secretome concentrations over time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hendrata, Melisa& Sudiono, Janti. 2016. A Computational Model for Investigating Tumor Apoptosis Induced by Mesenchymal Stem Cell-Derived Secretome. Computational and Mathematical Methods in Medicine،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1100141
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hendrata, Melisa& Sudiono, Janti. A Computational Model for Investigating Tumor Apoptosis Induced by Mesenchymal Stem Cell-Derived Secretome. Computational and Mathematical Methods in Medicine No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1100141
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hendrata, Melisa& Sudiono, Janti. A Computational Model for Investigating Tumor Apoptosis Induced by Mesenchymal Stem Cell-Derived Secretome. Computational and Mathematical Methods in Medicine. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1100141
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1100141
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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