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A Computational Model for Investigating Tumor Apoptosis Induced by Mesenchymal Stem Cell-Derived Secretome
Joint Authors
Hendrata, Melisa
Sudiono, Janti
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-09
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Apoptosis is a programmed cell death that occurs naturally in physiological and pathological conditions.
Defective apoptosis can trigger the development and progression of cancer.
Experiments suggest the ability of secretome derived from mesenchymal stem cells (MSC) to induce apoptosis in cancer cells.
We develop a hybrid discrete-continuous multiscale model to further investigate the effect of MSC-derived secretome in tumor growth.
The model encompasses three biological scales.
At the molecular scale, a system of ordinary differential equations regulate the expression of proteins involved in apoptosis signaling pathways.
At the cellular scale, discrete equations control cellular migration, phenotypic switching, and proliferation.
At the extracellular scale, a system of partial differential equations are employed to describe the dynamics of microenvironmental chemicals concentrations.
The simulation is able to produce both avascular tumor growth rate and phenotypic patterns as observed in the experiments.
In addition, we obtain good quantitative agreements with the experimental data on the apoptosis of HeLa cancer cells treated with MSC-derived secretome.
We use this model to predict the growth of avascular tumor under various secretome concentrations over time.
American Psychological Association (APA)
Hendrata, Melisa& Sudiono, Janti. 2016. A Computational Model for Investigating Tumor Apoptosis Induced by Mesenchymal Stem Cell-Derived Secretome. Computational and Mathematical Methods in Medicine،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1100141
Modern Language Association (MLA)
Hendrata, Melisa& Sudiono, Janti. A Computational Model for Investigating Tumor Apoptosis Induced by Mesenchymal Stem Cell-Derived Secretome. Computational and Mathematical Methods in Medicine No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1100141
American Medical Association (AMA)
Hendrata, Melisa& Sudiono, Janti. A Computational Model for Investigating Tumor Apoptosis Induced by Mesenchymal Stem Cell-Derived Secretome. Computational and Mathematical Methods in Medicine. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1100141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100141