In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies
المؤلفون المشاركون
Boukhabza, Maroua
El Hilaly, Jaouad
Attiya, Nourdine
El-Haidani, Ahmed
Filali-Zegzouti, Younes
Mazouzi, Driss
Amarouch, Mohamed-Yassine
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-02
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Ion channels are transmembrane proteins that allow the passage of ions according to the direction of their electrochemical gradients.
Mutations in more than 30 genes encoding ion channels have been associated with an increasingly wide range of inherited cardiac arrhythmias.
In this line, ion channels become one of the most important molecular targets for several classes of drugs, including antiarrhythmics.
Nevertheless, antiarrhythmic drugs are usually accompanied by some serious side effects.
Thus, developing new approaches could offer added values to prevent and treat the episodes of arrhythmia.
In this sense, green tea catechins seem to be a promising alternative because of the significant effect of Epigallocatechin-3-Gallate (E3G) on the electrocardiographic wave forms of guinea pig hearts.
Thus, the aim of this study was to evaluate the benefits-risks balance of E3G consumption in the setting of ion channel mutations linked with aberrant cardiac excitability phenotypes.
Two gain-of-function mutations, Nav1.5-p.R222Q and Nav1.5-p.I141V, which are linked with cardiac hyperexcitability phenotypes were studied.
Computer simulations of action potentials (APs) show that 30 μM E3G reduces and suppresses AP abnormalities characteristics of these phenotypes.
These results suggest that E3G may have a beneficial effect in the setting of cardiac sodium channelopathies displaying a hyperexcitability phenotype.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Boukhabza, Maroua& El Hilaly, Jaouad& Attiya, Nourdine& El-Haidani, Ahmed& Filali-Zegzouti, Younes& Mazouzi, Driss…[et al.]. 2016. In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies. Computational and Mathematical Methods in Medicine،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1100202
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Boukhabza, Maroua…[et al.]. In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies. Computational and Mathematical Methods in Medicine No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1100202
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Boukhabza, Maroua& El Hilaly, Jaouad& Attiya, Nourdine& El-Haidani, Ahmed& Filali-Zegzouti, Younes& Mazouzi, Driss…[et al.]. In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies. Computational and Mathematical Methods in Medicine. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1100202
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1100202
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر