In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies
Joint Authors
Boukhabza, Maroua
El Hilaly, Jaouad
Attiya, Nourdine
El-Haidani, Ahmed
Filali-Zegzouti, Younes
Mazouzi, Driss
Amarouch, Mohamed-Yassine
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-02
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Ion channels are transmembrane proteins that allow the passage of ions according to the direction of their electrochemical gradients.
Mutations in more than 30 genes encoding ion channels have been associated with an increasingly wide range of inherited cardiac arrhythmias.
In this line, ion channels become one of the most important molecular targets for several classes of drugs, including antiarrhythmics.
Nevertheless, antiarrhythmic drugs are usually accompanied by some serious side effects.
Thus, developing new approaches could offer added values to prevent and treat the episodes of arrhythmia.
In this sense, green tea catechins seem to be a promising alternative because of the significant effect of Epigallocatechin-3-Gallate (E3G) on the electrocardiographic wave forms of guinea pig hearts.
Thus, the aim of this study was to evaluate the benefits-risks balance of E3G consumption in the setting of ion channel mutations linked with aberrant cardiac excitability phenotypes.
Two gain-of-function mutations, Nav1.5-p.R222Q and Nav1.5-p.I141V, which are linked with cardiac hyperexcitability phenotypes were studied.
Computer simulations of action potentials (APs) show that 30 μM E3G reduces and suppresses AP abnormalities characteristics of these phenotypes.
These results suggest that E3G may have a beneficial effect in the setting of cardiac sodium channelopathies displaying a hyperexcitability phenotype.
American Psychological Association (APA)
Boukhabza, Maroua& El Hilaly, Jaouad& Attiya, Nourdine& El-Haidani, Ahmed& Filali-Zegzouti, Younes& Mazouzi, Driss…[et al.]. 2016. In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies. Computational and Mathematical Methods in Medicine،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1100202
Modern Language Association (MLA)
Boukhabza, Maroua…[et al.]. In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies. Computational and Mathematical Methods in Medicine No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1100202
American Medical Association (AMA)
Boukhabza, Maroua& El Hilaly, Jaouad& Attiya, Nourdine& El-Haidani, Ahmed& Filali-Zegzouti, Younes& Mazouzi, Driss…[et al.]. In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies. Computational and Mathematical Methods in Medicine. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1100202
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100202