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Familial Pemphigus Vulgaris Occured in a Father and Son as the First Confirmed Cases
المؤلفون المشاركون
Eskiocak, Ali Haydar
Ozkesici, Birgul
Uzun, S.
المصدر
Case Reports in Dermatological Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-15
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Pemphigus vulgaris (PV) is a chronic autoimmune bullous disease of the skin and mucous membranes.
Although there is some evidence pointing towards a genetic predisposition by some human leukocyte antigen (HLA) genes, familial occurrence of PV is very rare.
Most of the familial PV cases so far reported have been in mother and daughter and in siblings.
PV in father and son, as presented here, has not been reported in the literature before, except an unconfirmed report.
The diagnosis of PV was established by histologic, cytologic studies and enzyme linked immunosorbent assay (ELISA) in Case 1 and by ELISA and BIOCHIP indirect immunofluorescence test in Case 2.
The son was responsive to moderate doses of methylprednisolone, with the treatment continuing with tapered doses.
The father was in a subclinic condition; consequently, only close follow-up was recommended.
HLA typing studies revealed identical HLA alleles of HLA-DR4 (DRB1⁎04) and HLA-DQB1⁎03 in both of our cases; this had been found to be associated with PV in prior studies.
Familial occurrences of PV and related HLA genes indicate the importance of genetic predisposition.
The first occurrence of confirmed familial PV in father and son is reported here.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eskiocak, Ali Haydar& Ozkesici, Birgul& Uzun, S.. 2016. Familial Pemphigus Vulgaris Occured in a Father and Son as the First Confirmed Cases. Case Reports in Dermatological Medicine،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100636
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eskiocak, Ali Haydar…[et al.]. Familial Pemphigus Vulgaris Occured in a Father and Son as the First Confirmed Cases. Case Reports in Dermatological Medicine No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1100636
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eskiocak, Ali Haydar& Ozkesici, Birgul& Uzun, S.. Familial Pemphigus Vulgaris Occured in a Father and Son as the First Confirmed Cases. Case Reports in Dermatological Medicine. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100636
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1100636
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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