Familial Pemphigus Vulgaris Occured in a Father and Son as the First Confirmed Cases
Joint Authors
Eskiocak, Ali Haydar
Ozkesici, Birgul
Uzun, S.
Source
Case Reports in Dermatological Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Pemphigus vulgaris (PV) is a chronic autoimmune bullous disease of the skin and mucous membranes.
Although there is some evidence pointing towards a genetic predisposition by some human leukocyte antigen (HLA) genes, familial occurrence of PV is very rare.
Most of the familial PV cases so far reported have been in mother and daughter and in siblings.
PV in father and son, as presented here, has not been reported in the literature before, except an unconfirmed report.
The diagnosis of PV was established by histologic, cytologic studies and enzyme linked immunosorbent assay (ELISA) in Case 1 and by ELISA and BIOCHIP indirect immunofluorescence test in Case 2.
The son was responsive to moderate doses of methylprednisolone, with the treatment continuing with tapered doses.
The father was in a subclinic condition; consequently, only close follow-up was recommended.
HLA typing studies revealed identical HLA alleles of HLA-DR4 (DRB1⁎04) and HLA-DQB1⁎03 in both of our cases; this had been found to be associated with PV in prior studies.
Familial occurrences of PV and related HLA genes indicate the importance of genetic predisposition.
The first occurrence of confirmed familial PV in father and son is reported here.
American Psychological Association (APA)
Eskiocak, Ali Haydar& Ozkesici, Birgul& Uzun, S.. 2016. Familial Pemphigus Vulgaris Occured in a Father and Son as the First Confirmed Cases. Case Reports in Dermatological Medicine،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100636
Modern Language Association (MLA)
Eskiocak, Ali Haydar…[et al.]. Familial Pemphigus Vulgaris Occured in a Father and Son as the First Confirmed Cases. Case Reports in Dermatological Medicine No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1100636
American Medical Association (AMA)
Eskiocak, Ali Haydar& Ozkesici, Birgul& Uzun, S.. Familial Pemphigus Vulgaris Occured in a Father and Son as the First Confirmed Cases. Case Reports in Dermatological Medicine. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100636
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100636