The Biochemical Profile of Familial Hypocalciuric Hypercalcemia and Primary Hyperparathyroidism during Pregnancy and Lactation: Two Case Reports and Review of the Literature
المؤلفون المشاركون
Ghaznavi, S. A.
Saad, N. M. A.
Donovan, L. E.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Primary hyperparathyroidism (PHPT) and Familial Hypocalciuric Hypercalcemia (FHH) result in different maternal and fetal complications in pregnancy.
Calcium to creatinine clearance ratio (CCCR) is commonly used to help distinguish these two conditions.
Physiological changes in calcium handling during pregnancy and lactation can alter CCCR, making it a less useful tool to distinguish PHPT from FHH.
Cases.
A 25-year-old female presented with hypercalcemia and an inappropriately normal PTH.
Her CCCR was 0.79% before pregnancy and rose to 1.99% in her second trimester.
The proband’s mother and neonate had asymptomatic hypercalcemia.
Genetic analysis revealed a CaSR mutation consistent with FHH.
A 19-year-old female presented with a history of nephrolithiasis who underwent emergent caesarean section at 29 weeks of gestation for severe preeclampsia.
At delivery, she was diagnosed with hypercalcemia with an inappropriately normal PTH and a CCCR of 2.67%, which fell to 0.88% during lactation.
Parathyroidectomy cured her hypercalcemia.
Pathology confirmed a parathyroid adenoma.
Conclusion.
These cases illustrate the influence of pregnancy and lactation on renal calcium indices, such as the CCCR.
To avoid diagnostic error of women with hypercalcemia during pregnancy and lactation, calcium biochemistry of first-degree relatives and genetic testing of select patients are recommended.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghaznavi, S. A.& Saad, N. M. A.& Donovan, L. E.. 2016. The Biochemical Profile of Familial Hypocalciuric Hypercalcemia and Primary Hyperparathyroidism during Pregnancy and Lactation: Two Case Reports and Review of the Literature. Case Reports in Endocrinology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1100675
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghaznavi, S. A.…[et al.]. The Biochemical Profile of Familial Hypocalciuric Hypercalcemia and Primary Hyperparathyroidism during Pregnancy and Lactation: Two Case Reports and Review of the Literature. Case Reports in Endocrinology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1100675
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghaznavi, S. A.& Saad, N. M. A.& Donovan, L. E.. The Biochemical Profile of Familial Hypocalciuric Hypercalcemia and Primary Hyperparathyroidism during Pregnancy and Lactation: Two Case Reports and Review of the Literature. Case Reports in Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1100675
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1100675
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر