The Biochemical Profile of Familial Hypocalciuric Hypercalcemia and Primary Hyperparathyroidism during Pregnancy and Lactation: Two Case Reports and Review of the Literature
Joint Authors
Ghaznavi, S. A.
Saad, N. M. A.
Donovan, L. E.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Primary hyperparathyroidism (PHPT) and Familial Hypocalciuric Hypercalcemia (FHH) result in different maternal and fetal complications in pregnancy.
Calcium to creatinine clearance ratio (CCCR) is commonly used to help distinguish these two conditions.
Physiological changes in calcium handling during pregnancy and lactation can alter CCCR, making it a less useful tool to distinguish PHPT from FHH.
Cases.
A 25-year-old female presented with hypercalcemia and an inappropriately normal PTH.
Her CCCR was 0.79% before pregnancy and rose to 1.99% in her second trimester.
The proband’s mother and neonate had asymptomatic hypercalcemia.
Genetic analysis revealed a CaSR mutation consistent with FHH.
A 19-year-old female presented with a history of nephrolithiasis who underwent emergent caesarean section at 29 weeks of gestation for severe preeclampsia.
At delivery, she was diagnosed with hypercalcemia with an inappropriately normal PTH and a CCCR of 2.67%, which fell to 0.88% during lactation.
Parathyroidectomy cured her hypercalcemia.
Pathology confirmed a parathyroid adenoma.
Conclusion.
These cases illustrate the influence of pregnancy and lactation on renal calcium indices, such as the CCCR.
To avoid diagnostic error of women with hypercalcemia during pregnancy and lactation, calcium biochemistry of first-degree relatives and genetic testing of select patients are recommended.
American Psychological Association (APA)
Ghaznavi, S. A.& Saad, N. M. A.& Donovan, L. E.. 2016. The Biochemical Profile of Familial Hypocalciuric Hypercalcemia and Primary Hyperparathyroidism during Pregnancy and Lactation: Two Case Reports and Review of the Literature. Case Reports in Endocrinology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1100675
Modern Language Association (MLA)
Ghaznavi, S. A.…[et al.]. The Biochemical Profile of Familial Hypocalciuric Hypercalcemia and Primary Hyperparathyroidism during Pregnancy and Lactation: Two Case Reports and Review of the Literature. Case Reports in Endocrinology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1100675
American Medical Association (AMA)
Ghaznavi, S. A.& Saad, N. M. A.& Donovan, L. E.. The Biochemical Profile of Familial Hypocalciuric Hypercalcemia and Primary Hyperparathyroidism during Pregnancy and Lactation: Two Case Reports and Review of the Literature. Case Reports in Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1100675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100675