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Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy
المؤلفون المشاركون
Endo, Tomoyuki
Teshima, Takanori
Kasahara, Kohei
Onozawa, Masahiro
Miyashita, Naohiro
Yokohata, Emi
Yoshida, Miho
Kanaya, Minoru
Kosugi-Kanaya, Mizuha
Takemura, Ryo
Takahashi, Shojiro
Sugita, Junichi
Shigematsu, Akio
Takahata, Mutsumi
Fujisawa, Shinichi
Hashimoto, Daigo
Fujimoto, Katsuya
Kondo, Takeshi
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-10
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
We report a case of acute myeloid leukemia (AML) with two cytogenetically unrelated clones.
The patient was a 45-year-old male who was diagnosed with acute monoblastic leukemia (AMoL).
Initial G-band analysis showed 51,XY,+6,+8,inv(9)(p12q13)c,+11,+13,+19[12]/52,idem,+Y[8], but G-band analysis after induction therapy showed 45,XY,-7,inv(9)(p12q13)c[19]/46,XY,inv(9)(p12q13)c[1].
Retrospective FISH analysis revealed a cryptic monosomy 7 clone in the initial AML sample.
The clone with multiple trisomies was eliminated after induction therapy and never recurred, but a clone with monosomy 7 was still detected in myelodysplastic marrow with a normal blast percentage.
Both clones were successfully eliminated after related peripheral blood stem cell transplantation, but the patient died of relapsed AML with monosomy 7.
We concluded that one clone was de novo AMoL with chromosome 6, 8, 11, 13, and 19 trisomy and that the other was acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) with chromosome 7 monosomy showing different responses to chemotherapy.
Simultaneous onset of cytogenetically unrelated hematological malignancies that each have a different disease status is a rare phenomenon but is important to diagnose for a correct understanding of the disease status and for establishing an appropriate treatment strategy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kasahara, Kohei& Onozawa, Masahiro& Miyashita, Naohiro& Yokohata, Emi& Yoshida, Miho& Kanaya, Minoru…[et al.]. 2016. Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy. Case Reports in Hematology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1100838
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kasahara, Kohei…[et al.]. Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy. Case Reports in Hematology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1100838
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kasahara, Kohei& Onozawa, Masahiro& Miyashita, Naohiro& Yokohata, Emi& Yoshida, Miho& Kanaya, Minoru…[et al.]. Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy. Case Reports in Hematology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1100838
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1100838
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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