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Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy
Joint Authors
Endo, Tomoyuki
Teshima, Takanori
Kasahara, Kohei
Onozawa, Masahiro
Miyashita, Naohiro
Yokohata, Emi
Yoshida, Miho
Kanaya, Minoru
Kosugi-Kanaya, Mizuha
Takemura, Ryo
Takahashi, Shojiro
Sugita, Junichi
Shigematsu, Akio
Takahata, Mutsumi
Fujisawa, Shinichi
Hashimoto, Daigo
Fujimoto, Katsuya
Kondo, Takeshi
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We report a case of acute myeloid leukemia (AML) with two cytogenetically unrelated clones.
The patient was a 45-year-old male who was diagnosed with acute monoblastic leukemia (AMoL).
Initial G-band analysis showed 51,XY,+6,+8,inv(9)(p12q13)c,+11,+13,+19[12]/52,idem,+Y[8], but G-band analysis after induction therapy showed 45,XY,-7,inv(9)(p12q13)c[19]/46,XY,inv(9)(p12q13)c[1].
Retrospective FISH analysis revealed a cryptic monosomy 7 clone in the initial AML sample.
The clone with multiple trisomies was eliminated after induction therapy and never recurred, but a clone with monosomy 7 was still detected in myelodysplastic marrow with a normal blast percentage.
Both clones were successfully eliminated after related peripheral blood stem cell transplantation, but the patient died of relapsed AML with monosomy 7.
We concluded that one clone was de novo AMoL with chromosome 6, 8, 11, 13, and 19 trisomy and that the other was acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) with chromosome 7 monosomy showing different responses to chemotherapy.
Simultaneous onset of cytogenetically unrelated hematological malignancies that each have a different disease status is a rare phenomenon but is important to diagnose for a correct understanding of the disease status and for establishing an appropriate treatment strategy.
American Psychological Association (APA)
Kasahara, Kohei& Onozawa, Masahiro& Miyashita, Naohiro& Yokohata, Emi& Yoshida, Miho& Kanaya, Minoru…[et al.]. 2016. Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy. Case Reports in Hematology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1100838
Modern Language Association (MLA)
Kasahara, Kohei…[et al.]. Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy. Case Reports in Hematology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1100838
American Medical Association (AMA)
Kasahara, Kohei& Onozawa, Masahiro& Miyashita, Naohiro& Yokohata, Emi& Yoshida, Miho& Kanaya, Minoru…[et al.]. Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy. Case Reports in Hematology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1100838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100838