Simeprevir and Sofosbuvir Combination Treatment in a Patient with HCV Cirrhosis and HbS Beta 0-Thalassemia: Efficacy and Safety despite Baseline Hyperbilirubinemia
المؤلفون المشاركون
Papadopoulos, Nikolaos
Deutsch, Melanie
Georgalas, Athanasios
Poulakidas, Helias
Karnesis, Lazaros
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-02
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Hyperbilirubinemia is an adverse reaction of simeprevir (SMV).
The majority of these patients were taking concurrent ribavirin presenting elevated unconjugated hyperbilirubinemia due to hemolysis.
However, cases of hepatic failure with elevated bilirubin level have also been reported in patients with decompensated cirrhosis.
We describe a 51-year-old female patient with HbS beta 0-thalassemia and recently diagnosed compensated cirrhosis due to chronic hepatitis C infection.
Laboratory evaluation revealed total bilirubin: 2.7 mg/dL and serum HCV-RNA 137.204 IU/mL.
HCV was genotyped as 4.
A FibroScan revealed 35.3 kPa.
She was considered as illegible for pegylated-interferon-free treatment with direct acting antivirals and a course with simeprevir and sofosbuvir (SOF) combination for twelve weeks was planned.
Hyperbilirubinemia developed from the beginning with peak values during the 3rd month of treatment.
However, no findings of liver decompensation were noticed.
Hyperbilirubinemia was benign and fully reversible and our patient finally achieved sustained virological response 24 weeks after the end of treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Papadopoulos, Nikolaos& Deutsch, Melanie& Georgalas, Athanasios& Poulakidas, Helias& Karnesis, Lazaros. 2016. Simeprevir and Sofosbuvir Combination Treatment in a Patient with HCV Cirrhosis and HbS Beta 0-Thalassemia: Efficacy and Safety despite Baseline Hyperbilirubinemia. Case Reports in Hematology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100881
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Papadopoulos, Nikolaos…[et al.]. Simeprevir and Sofosbuvir Combination Treatment in a Patient with HCV Cirrhosis and HbS Beta 0-Thalassemia: Efficacy and Safety despite Baseline Hyperbilirubinemia. Case Reports in Hematology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1100881
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Papadopoulos, Nikolaos& Deutsch, Melanie& Georgalas, Athanasios& Poulakidas, Helias& Karnesis, Lazaros. Simeprevir and Sofosbuvir Combination Treatment in a Patient with HCV Cirrhosis and HbS Beta 0-Thalassemia: Efficacy and Safety despite Baseline Hyperbilirubinemia. Case Reports in Hematology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100881
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1100881
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر