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Simeprevir and Sofosbuvir Combination Treatment in a Patient with HCV Cirrhosis and HbS Beta 0-Thalassemia: Efficacy and Safety despite Baseline Hyperbilirubinemia
Joint Authors
Papadopoulos, Nikolaos
Deutsch, Melanie
Georgalas, Athanasios
Poulakidas, Helias
Karnesis, Lazaros
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-02
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hyperbilirubinemia is an adverse reaction of simeprevir (SMV).
The majority of these patients were taking concurrent ribavirin presenting elevated unconjugated hyperbilirubinemia due to hemolysis.
However, cases of hepatic failure with elevated bilirubin level have also been reported in patients with decompensated cirrhosis.
We describe a 51-year-old female patient with HbS beta 0-thalassemia and recently diagnosed compensated cirrhosis due to chronic hepatitis C infection.
Laboratory evaluation revealed total bilirubin: 2.7 mg/dL and serum HCV-RNA 137.204 IU/mL.
HCV was genotyped as 4.
A FibroScan revealed 35.3 kPa.
She was considered as illegible for pegylated-interferon-free treatment with direct acting antivirals and a course with simeprevir and sofosbuvir (SOF) combination for twelve weeks was planned.
Hyperbilirubinemia developed from the beginning with peak values during the 3rd month of treatment.
However, no findings of liver decompensation were noticed.
Hyperbilirubinemia was benign and fully reversible and our patient finally achieved sustained virological response 24 weeks after the end of treatment.
American Psychological Association (APA)
Papadopoulos, Nikolaos& Deutsch, Melanie& Georgalas, Athanasios& Poulakidas, Helias& Karnesis, Lazaros. 2016. Simeprevir and Sofosbuvir Combination Treatment in a Patient with HCV Cirrhosis and HbS Beta 0-Thalassemia: Efficacy and Safety despite Baseline Hyperbilirubinemia. Case Reports in Hematology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100881
Modern Language Association (MLA)
Papadopoulos, Nikolaos…[et al.]. Simeprevir and Sofosbuvir Combination Treatment in a Patient with HCV Cirrhosis and HbS Beta 0-Thalassemia: Efficacy and Safety despite Baseline Hyperbilirubinemia. Case Reports in Hematology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1100881
American Medical Association (AMA)
Papadopoulos, Nikolaos& Deutsch, Melanie& Georgalas, Athanasios& Poulakidas, Helias& Karnesis, Lazaros. Simeprevir and Sofosbuvir Combination Treatment in a Patient with HCV Cirrhosis and HbS Beta 0-Thalassemia: Efficacy and Safety despite Baseline Hyperbilirubinemia. Case Reports in Hematology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100881