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Acute and Fatal Isoniazid-Induced Hepatotoxicity: A Case Report and Review of the Literature
المؤلفون المشاركون
Kabbara, Wissam K.
Sarkis, Aline T.
Saroufim, Paola G.
المصدر
Case Reports in Infectious Diseases
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-25
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
This paper describes a case of an acute and fatal isoniazid-induced hepatotoxicity and provides a review of the literature.
A 65-year-old female diagnosed with latent Mycobacterium tuberculosis infection was receiving oral isoniazid 300 mg daily.
She was admitted to the hospital for epigastric and right sided flank pain of one-week duration.
Laboratory results and imaging confirmed hepatitis.
After ruling out all other possible causes, she was diagnosed with isoniazid-induced acute hepatitis (probable association by the Naranjo scale).
After discharge, the patient was readmitted and suffered from severe coagulopathy, metabolic acidosis, acute kidney injury, hepatic encephalopathy, and cardiorespiratory arrest necessitating two rounds of cardiopulmonary resuscitation.
Despite maximal hemodynamic support, the patient did not survive.
A review of the literature, from several European countries and the United States of America, revealed a low incidence of mortality due to isoniazid-induced hepatotoxicity when used as a single agent for latent Mycobacterium tuberculosis infection.
As for the management, the first step consists of withdrawing isoniazid and rechallenge is usually discouraged.
Few treatment modalities have been proposed; however there is no robust evidence to support any of them.
Routine monitoring for hepatotoxicity in patients receiving isoniazid is warranted to prevent morbidity and mortality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kabbara, Wissam K.& Sarkis, Aline T.& Saroufim, Paola G.. 2016. Acute and Fatal Isoniazid-Induced Hepatotoxicity: A Case Report and Review of the Literature. Case Reports in Infectious Diseases،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1100967
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kabbara, Wissam K.…[et al.]. Acute and Fatal Isoniazid-Induced Hepatotoxicity: A Case Report and Review of the Literature. Case Reports in Infectious Diseases No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1100967
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kabbara, Wissam K.& Sarkis, Aline T.& Saroufim, Paola G.. Acute and Fatal Isoniazid-Induced Hepatotoxicity: A Case Report and Review of the Literature. Case Reports in Infectious Diseases. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1100967
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1100967
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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