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Acute and Fatal Isoniazid-Induced Hepatotoxicity: A Case Report and Review of the Literature
Joint Authors
Kabbara, Wissam K.
Sarkis, Aline T.
Saroufim, Paola G.
Source
Case Reports in Infectious Diseases
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This paper describes a case of an acute and fatal isoniazid-induced hepatotoxicity and provides a review of the literature.
A 65-year-old female diagnosed with latent Mycobacterium tuberculosis infection was receiving oral isoniazid 300 mg daily.
She was admitted to the hospital for epigastric and right sided flank pain of one-week duration.
Laboratory results and imaging confirmed hepatitis.
After ruling out all other possible causes, she was diagnosed with isoniazid-induced acute hepatitis (probable association by the Naranjo scale).
After discharge, the patient was readmitted and suffered from severe coagulopathy, metabolic acidosis, acute kidney injury, hepatic encephalopathy, and cardiorespiratory arrest necessitating two rounds of cardiopulmonary resuscitation.
Despite maximal hemodynamic support, the patient did not survive.
A review of the literature, from several European countries and the United States of America, revealed a low incidence of mortality due to isoniazid-induced hepatotoxicity when used as a single agent for latent Mycobacterium tuberculosis infection.
As for the management, the first step consists of withdrawing isoniazid and rechallenge is usually discouraged.
Few treatment modalities have been proposed; however there is no robust evidence to support any of them.
Routine monitoring for hepatotoxicity in patients receiving isoniazid is warranted to prevent morbidity and mortality.
American Psychological Association (APA)
Kabbara, Wissam K.& Sarkis, Aline T.& Saroufim, Paola G.. 2016. Acute and Fatal Isoniazid-Induced Hepatotoxicity: A Case Report and Review of the Literature. Case Reports in Infectious Diseases،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1100967
Modern Language Association (MLA)
Kabbara, Wissam K.…[et al.]. Acute and Fatal Isoniazid-Induced Hepatotoxicity: A Case Report and Review of the Literature. Case Reports in Infectious Diseases No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1100967
American Medical Association (AMA)
Kabbara, Wissam K.& Sarkis, Aline T.& Saroufim, Paola G.. Acute and Fatal Isoniazid-Induced Hepatotoxicity: A Case Report and Review of the Literature. Case Reports in Infectious Diseases. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1100967
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1100967