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Treatment of Light Chain Deposition Disease Using Bortezomib-Based Regimen Followed by Thalidomide-Based Regimen in a Saudi Male
المؤلفون المشاركون
Adamu, B.
Al-Ghamdi, Mushabab
Ahmad, Mustafa
Alsaad, Khaled O.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-19
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Light chain deposition disease (LCDD) is a rare illness with, as yet, no clear evidence-based guidelines for its treatment.
To the best of our knowledge, LCDD has not been previously reported from Saudi Arabia.
We present in this report, a 38-year-old Saudi male who presented with clinical features suggestive of hypertensive nephropathy but kidney biopsy later revealed the diagnosis of LCDD.
His serum creatinine at presentation was 297 μmol/L which came down to 194 μmol/L on treatment with Bortezomib, Cyclophosphamide and Dexamethasone.
His 24-hour protein excretion at presentation was 6 g/L which also came down to less than 1 g/day.
He was later placed on Cyclophosphamide, Thalidomide, and Dexamethasone regimen because of persistent high titres of serum free light chains.
He went into remission with undetectable serum free light chains and remained so for three years at the time of writing this report.
We conclude that LCDD, though rare, does occur in Saudi population.
The treatment of LCDD is challenging but the use of Bortezomib, a proteosome inhibitor, is promising.
However, suboptimal response may require further treatment with other therapeutic options such as chemotherapy with alkylating agents or high-dose Melphalan with autologous stem cell transplant.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adamu, B.& Al-Ghamdi, Mushabab& Ahmad, Mustafa& Alsaad, Khaled O.. 2016. Treatment of Light Chain Deposition Disease Using Bortezomib-Based Regimen Followed by Thalidomide-Based Regimen in a Saudi Male. Case Reports in Nephrology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101231
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adamu, B.…[et al.]. Treatment of Light Chain Deposition Disease Using Bortezomib-Based Regimen Followed by Thalidomide-Based Regimen in a Saudi Male. Case Reports in Nephrology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1101231
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adamu, B.& Al-Ghamdi, Mushabab& Ahmad, Mustafa& Alsaad, Khaled O.. Treatment of Light Chain Deposition Disease Using Bortezomib-Based Regimen Followed by Thalidomide-Based Regimen in a Saudi Male. Case Reports in Nephrology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101231
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1101231
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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