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Treatment of Light Chain Deposition Disease Using Bortezomib-Based Regimen Followed by Thalidomide-Based Regimen in a Saudi Male
Joint Authors
Adamu, B.
Al-Ghamdi, Mushabab
Ahmad, Mustafa
Alsaad, Khaled O.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-19
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Light chain deposition disease (LCDD) is a rare illness with, as yet, no clear evidence-based guidelines for its treatment.
To the best of our knowledge, LCDD has not been previously reported from Saudi Arabia.
We present in this report, a 38-year-old Saudi male who presented with clinical features suggestive of hypertensive nephropathy but kidney biopsy later revealed the diagnosis of LCDD.
His serum creatinine at presentation was 297 μmol/L which came down to 194 μmol/L on treatment with Bortezomib, Cyclophosphamide and Dexamethasone.
His 24-hour protein excretion at presentation was 6 g/L which also came down to less than 1 g/day.
He was later placed on Cyclophosphamide, Thalidomide, and Dexamethasone regimen because of persistent high titres of serum free light chains.
He went into remission with undetectable serum free light chains and remained so for three years at the time of writing this report.
We conclude that LCDD, though rare, does occur in Saudi population.
The treatment of LCDD is challenging but the use of Bortezomib, a proteosome inhibitor, is promising.
However, suboptimal response may require further treatment with other therapeutic options such as chemotherapy with alkylating agents or high-dose Melphalan with autologous stem cell transplant.
American Psychological Association (APA)
Adamu, B.& Al-Ghamdi, Mushabab& Ahmad, Mustafa& Alsaad, Khaled O.. 2016. Treatment of Light Chain Deposition Disease Using Bortezomib-Based Regimen Followed by Thalidomide-Based Regimen in a Saudi Male. Case Reports in Nephrology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101231
Modern Language Association (MLA)
Adamu, B.…[et al.]. Treatment of Light Chain Deposition Disease Using Bortezomib-Based Regimen Followed by Thalidomide-Based Regimen in a Saudi Male. Case Reports in Nephrology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1101231
American Medical Association (AMA)
Adamu, B.& Al-Ghamdi, Mushabab& Ahmad, Mustafa& Alsaad, Khaled O.. Treatment of Light Chain Deposition Disease Using Bortezomib-Based Regimen Followed by Thalidomide-Based Regimen in a Saudi Male. Case Reports in Nephrology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101231