RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias

المؤلفون المشاركون

Galati, Francesca
Galati, Antonio
Massari, Serafina

المصدر

Cardiology Research and Practice

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-01-20

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض

الملخص EN

Ventricular arrhythmias are one of the most common causes of death in developed countries.

The use of implantable cardiac defibrillators is the most effective treatment to prevent sudden cardiac death.

To date, the ejection fraction is the only approved clinical variable used to determine suitability for defibrillator placement in subjects with heart failure.

The purpose of this study was to assess whether genetic polymorphisms found in the ryanodine receptor type 2 (Q2958R) and histidine-rich calcium-binding protein (S96A) might serve as markers for arrhythmias.

Genotyping was performed in 235 patients treated with defibrillator for primary and secondary prevention of arrhythmias.

No significant association was found between the S96A polymorphism and arrhythmia onset, whereas the QQ2958 genotype in the ryanodine receptor gene was correlated with an increased risk of life-threatening arrhythmias.

Concurrent stressor conditions, such as hypertension, seem to increase this effect.

Our findings might help to better identify patients who could benefit from defibrillator implantation.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Galati, Francesca& Galati, Antonio& Massari, Serafina. 2016. RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103279

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Galati, Francesca…[et al.]. RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias. Cardiology Research and Practice No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103279

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Galati, Francesca& Galati, Antonio& Massari, Serafina. RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103279

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1103279