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RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias
Joint Authors
Galati, Francesca
Galati, Antonio
Massari, Serafina
Source
Cardiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ventricular arrhythmias are one of the most common causes of death in developed countries.
The use of implantable cardiac defibrillators is the most effective treatment to prevent sudden cardiac death.
To date, the ejection fraction is the only approved clinical variable used to determine suitability for defibrillator placement in subjects with heart failure.
The purpose of this study was to assess whether genetic polymorphisms found in the ryanodine receptor type 2 (Q2958R) and histidine-rich calcium-binding protein (S96A) might serve as markers for arrhythmias.
Genotyping was performed in 235 patients treated with defibrillator for primary and secondary prevention of arrhythmias.
No significant association was found between the S96A polymorphism and arrhythmia onset, whereas the QQ2958 genotype in the ryanodine receptor gene was correlated with an increased risk of life-threatening arrhythmias.
Concurrent stressor conditions, such as hypertension, seem to increase this effect.
Our findings might help to better identify patients who could benefit from defibrillator implantation.
American Psychological Association (APA)
Galati, Francesca& Galati, Antonio& Massari, Serafina. 2016. RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103279
Modern Language Association (MLA)
Galati, Francesca…[et al.]. RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias. Cardiology Research and Practice No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103279
American Medical Association (AMA)
Galati, Francesca& Galati, Antonio& Massari, Serafina. RyR2 QQ2958 Genotype and Risk of Malignant Ventricular Arrhythmias. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103279