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Progenitor Hematopoietic Cells Implantation Improves Functional Capacity of End Stage Coronary Artery Disease Patients with Advanced Heart Failure
المؤلفون المشاركون
Yuniadi, Yoga
Kusnadi, Yuyus
Sandhow, Lakshmi
Erika, Rendra
Hanafy, Dicky A.
Sardjono, Caroline
Kaligis, R. W. M.
Kasim, Manoefris
Harimurti, Ganesja M.
المصدر
Cardiology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Proangiogenic Hematopoietic Cells (PHC) which comprise diverse mixture of cell types are able to secrete proangiogenic factors and interesting candidate for cell therapy.
The aim of this study was to seek for benefit in implantation of PHC on functional improvement in end stage coronary artery disease patients with advanced heart failure.
Methods.
Patients with symptomatic heart failure despite guideline directed medical therapy and LVEF less than 35% were included.
Peripheral blood mononuclear cells were isolated, cultivated for 5 days, and then harvested.
Flow cytometry and cell surface markers were used to characterize PHC.
The PHC were delivered retrogradely via sinus coronarius.
Echocardiography, myocardial perfusion, and clinical and functional data were analyzed up to 1-year observation.
Results.
Of 30 patients ( 56.4 ± 7.40 yo) preimplant NT proBNP level is 5124.5 ± 4682.50 pmol/L.
Harvested cells characterized with CD133, CD34, CD45, and KDR showed 0.87 ± 0.41 , 0.63 ± 0.66 , 99.00 ± 2.60 , and 3.22 ± 3.79 %, respectively.
LVEF was improved ( 22 ± 5.68 versus 26.8 ± 7.93 , p < 0.001 ) during short and long term observation.
Myocardial perfusion significantly improved 6 months after treatment.
NYHA Class and six-minute walk test are improved during short term and long term follow-up.
Conclusion.
Expanded peripheral blood PHC implantation using retrograde delivery approach improved LV systolic function, myocardial perfusion, and functional capacity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yuniadi, Yoga& Kusnadi, Yuyus& Sandhow, Lakshmi& Erika, Rendra& Hanafy, Dicky A.& Sardjono, Caroline…[et al.]. 2016. Progenitor Hematopoietic Cells Implantation Improves Functional Capacity of End Stage Coronary Artery Disease Patients with Advanced Heart Failure. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103282
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yuniadi, Yoga…[et al.]. Progenitor Hematopoietic Cells Implantation Improves Functional Capacity of End Stage Coronary Artery Disease Patients with Advanced Heart Failure. Cardiology Research and Practice No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103282
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yuniadi, Yoga& Kusnadi, Yuyus& Sandhow, Lakshmi& Erika, Rendra& Hanafy, Dicky A.& Sardjono, Caroline…[et al.]. Progenitor Hematopoietic Cells Implantation Improves Functional Capacity of End Stage Coronary Artery Disease Patients with Advanced Heart Failure. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103282
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103282
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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