Progenitor Hematopoietic Cells Implantation Improves Functional Capacity of End Stage Coronary Artery Disease Patients with Advanced Heart Failure
Joint Authors
Yuniadi, Yoga
Kusnadi, Yuyus
Sandhow, Lakshmi
Erika, Rendra
Hanafy, Dicky A.
Sardjono, Caroline
Kaligis, R. W. M.
Kasim, Manoefris
Harimurti, Ganesja M.
Source
Cardiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Proangiogenic Hematopoietic Cells (PHC) which comprise diverse mixture of cell types are able to secrete proangiogenic factors and interesting candidate for cell therapy.
The aim of this study was to seek for benefit in implantation of PHC on functional improvement in end stage coronary artery disease patients with advanced heart failure.
Methods.
Patients with symptomatic heart failure despite guideline directed medical therapy and LVEF less than 35% were included.
Peripheral blood mononuclear cells were isolated, cultivated for 5 days, and then harvested.
Flow cytometry and cell surface markers were used to characterize PHC.
The PHC were delivered retrogradely via sinus coronarius.
Echocardiography, myocardial perfusion, and clinical and functional data were analyzed up to 1-year observation.
Results.
Of 30 patients ( 56.4 ± 7.40 yo) preimplant NT proBNP level is 5124.5 ± 4682.50 pmol/L.
Harvested cells characterized with CD133, CD34, CD45, and KDR showed 0.87 ± 0.41 , 0.63 ± 0.66 , 99.00 ± 2.60 , and 3.22 ± 3.79 %, respectively.
LVEF was improved ( 22 ± 5.68 versus 26.8 ± 7.93 , p < 0.001 ) during short and long term observation.
Myocardial perfusion significantly improved 6 months after treatment.
NYHA Class and six-minute walk test are improved during short term and long term follow-up.
Conclusion.
Expanded peripheral blood PHC implantation using retrograde delivery approach improved LV systolic function, myocardial perfusion, and functional capacity.
American Psychological Association (APA)
Yuniadi, Yoga& Kusnadi, Yuyus& Sandhow, Lakshmi& Erika, Rendra& Hanafy, Dicky A.& Sardjono, Caroline…[et al.]. 2016. Progenitor Hematopoietic Cells Implantation Improves Functional Capacity of End Stage Coronary Artery Disease Patients with Advanced Heart Failure. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103282
Modern Language Association (MLA)
Yuniadi, Yoga…[et al.]. Progenitor Hematopoietic Cells Implantation Improves Functional Capacity of End Stage Coronary Artery Disease Patients with Advanced Heart Failure. Cardiology Research and Practice No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103282
American Medical Association (AMA)
Yuniadi, Yoga& Kusnadi, Yuyus& Sandhow, Lakshmi& Erika, Rendra& Hanafy, Dicky A.& Sardjono, Caroline…[et al.]. Progenitor Hematopoietic Cells Implantation Improves Functional Capacity of End Stage Coronary Artery Disease Patients with Advanced Heart Failure. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103282