Expression of Cancer Testis Antigens in Colorectal Cancer: New Prognostic and Therapeutic Implications
المؤلفون المشاركون
Safranow, Krzysztof
Urasinska, Elzbieta
Tarnowski, Maciej
Czerewaty, Michał
Deskur, Anna
Marlicz, Wojciech
Starzyńska, Teresa
Ratajczak, Mariusz Z.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
While cancer/testis antigens (CTAs) are restricted in postnatal tissues to testes and germ line-derived cells, their role in cancer development and the clinical significance of their expression still remain to be better defined.
Objective.
The aim of this study was to investigate the level of CTA expression in colon samples from patients with colorectal cancer (CRC) in relation to patient clinical status.
Methods.
Forty-five patients with newly diagnosed colorectal cancer were included in the study.
We selected a panel of 18 CTAs that were previously detected in CRC as well as some new gene candidates, and their expression was detected at the mRNA level by employing RQ-PCR.
Additionally, we evaluated CTA expression in three colon cancer cell lines (CL-188, HTB-39, and HTB-37) after exposure to the DNA methylation-modifying drug 5-azacytidine.
Results.
We report that 6 out of 18 (33%) CTAs tested (MAGEA3, OIP5, TTK, PLU1, DKKL1, and FBXO39) were significantly ( p < 0.05 ) overexpressed in tumor tissue compared with healthy colon samples isolated from the same patients.
Conclusions.
Moreover, we found that MAGEA3, PLU-1, and DKKL expression positively correlated with disease progression, evaluated according to the Dukes staging system.
Finally, 5-azacytidine exposure significantly upregulated expression of CTAs on CRC cells, which indicates that this demethylation agent could be employed therapeutically to enhance the immune response against tumor cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tarnowski, Maciej& Czerewaty, Michał& Deskur, Anna& Safranow, Krzysztof& Marlicz, Wojciech& Urasinska, Elzbieta…[et al.]. 2016. Expression of Cancer Testis Antigens in Colorectal Cancer: New Prognostic and Therapeutic Implications. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103665
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tarnowski, Maciej…[et al.]. Expression of Cancer Testis Antigens in Colorectal Cancer: New Prognostic and Therapeutic Implications. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103665
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tarnowski, Maciej& Czerewaty, Michał& Deskur, Anna& Safranow, Krzysztof& Marlicz, Wojciech& Urasinska, Elzbieta…[et al.]. Expression of Cancer Testis Antigens in Colorectal Cancer: New Prognostic and Therapeutic Implications. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103665
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103665
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر