Detection of Soluble ED-A+ Fibronectin and Evaluation as Novel Serum Biomarker for Cardiac Tissue Remodeling
المؤلفون المشاركون
Jung, Christian
Figulla, Hans Reiner
Pfeil, Alexander
Ziffels, Barbara
Ospel, Johanna
Grün, Katja
Neri, Dario
Franz, Marcus
Fritzenwanger, Michael
Berndt, Alexander
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background and Aims.
Fibronectin containing the extra domain A (ED-A+ Fn) was proven to serve as a valuable biomarker for cardiac remodeling.
The study was aimed at establishing an ELISA to determine ED-A+ Fn in serum of heart failure patients.
Methods.
ED-A+ Fn was quantified in serum samples from 114 heart failure patients due to ischemic (ICM, n = 44 ) and dilated (DCM, n = 39 ) cardiomyopathy as well as hypertensive heart disease (HHD, n = 31 ) compared to healthy controls ( n = 12 ).
Results.
In comparison to healthy volunteers, heart failure patients showed significantly increased levels of ED-A+ Fn ( p < 0.001 ).
In particular in ICM patients there were significant associations between ED-A+ Fn serum levels and clinical parameters, for example, increased levels with rising NYHA class ( p = 0.013 ), a negative correlation with left ventricular ejection fraction ( p = 0.026 , r : −0.353), a positive correlation with left atrial diameter ( p = 0.008 , r : 0.431), and a strong positive correlation with systolic pulmonary artery pressure ( p = 0.002 , r : 0.485).
In multivariate analysis, ED-A+ Fn was identified as an independent predictor of an ischemic heart failure etiology.
Conclusions.
The current study could clearly show that ED-A+ Fn is a promising biomarker in cardiovascular diseases, especially in heart failure patients due to an ICM.
We presented a valid ELISA method, which could be applied for further studies investigating the value of ED-A+ Fn.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ziffels, Barbara& Ospel, Johanna& Grün, Katja& Neri, Dario& Pfeil, Alexander& Fritzenwanger, Michael…[et al.]. 2016. Detection of Soluble ED-A+ Fibronectin and Evaluation as Novel Serum Biomarker for Cardiac Tissue Remodeling. Disease Markers،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1103693
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ziffels, Barbara…[et al.]. Detection of Soluble ED-A+ Fibronectin and Evaluation as Novel Serum Biomarker for Cardiac Tissue Remodeling. Disease Markers No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1103693
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ziffels, Barbara& Ospel, Johanna& Grün, Katja& Neri, Dario& Pfeil, Alexander& Fritzenwanger, Michael…[et al.]. Detection of Soluble ED-A+ Fibronectin and Evaluation as Novel Serum Biomarker for Cardiac Tissue Remodeling. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1103693
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103693
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر