Detection of Soluble ED-A+ Fibronectin and Evaluation as Novel Serum Biomarker for Cardiac Tissue Remodeling
Joint Authors
Jung, Christian
Figulla, Hans Reiner
Pfeil, Alexander
Ziffels, Barbara
Ospel, Johanna
Grün, Katja
Neri, Dario
Franz, Marcus
Fritzenwanger, Michael
Berndt, Alexander
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background and Aims.
Fibronectin containing the extra domain A (ED-A+ Fn) was proven to serve as a valuable biomarker for cardiac remodeling.
The study was aimed at establishing an ELISA to determine ED-A+ Fn in serum of heart failure patients.
Methods.
ED-A+ Fn was quantified in serum samples from 114 heart failure patients due to ischemic (ICM, n = 44 ) and dilated (DCM, n = 39 ) cardiomyopathy as well as hypertensive heart disease (HHD, n = 31 ) compared to healthy controls ( n = 12 ).
Results.
In comparison to healthy volunteers, heart failure patients showed significantly increased levels of ED-A+ Fn ( p < 0.001 ).
In particular in ICM patients there were significant associations between ED-A+ Fn serum levels and clinical parameters, for example, increased levels with rising NYHA class ( p = 0.013 ), a negative correlation with left ventricular ejection fraction ( p = 0.026 , r : −0.353), a positive correlation with left atrial diameter ( p = 0.008 , r : 0.431), and a strong positive correlation with systolic pulmonary artery pressure ( p = 0.002 , r : 0.485).
In multivariate analysis, ED-A+ Fn was identified as an independent predictor of an ischemic heart failure etiology.
Conclusions.
The current study could clearly show that ED-A+ Fn is a promising biomarker in cardiovascular diseases, especially in heart failure patients due to an ICM.
We presented a valid ELISA method, which could be applied for further studies investigating the value of ED-A+ Fn.
American Psychological Association (APA)
Ziffels, Barbara& Ospel, Johanna& Grün, Katja& Neri, Dario& Pfeil, Alexander& Fritzenwanger, Michael…[et al.]. 2016. Detection of Soluble ED-A+ Fibronectin and Evaluation as Novel Serum Biomarker for Cardiac Tissue Remodeling. Disease Markers،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1103693
Modern Language Association (MLA)
Ziffels, Barbara…[et al.]. Detection of Soluble ED-A+ Fibronectin and Evaluation as Novel Serum Biomarker for Cardiac Tissue Remodeling. Disease Markers No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1103693
American Medical Association (AMA)
Ziffels, Barbara& Ospel, Johanna& Grün, Katja& Neri, Dario& Pfeil, Alexander& Fritzenwanger, Michael…[et al.]. Detection of Soluble ED-A+ Fibronectin and Evaluation as Novel Serum Biomarker for Cardiac Tissue Remodeling. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1103693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103693