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Association of the MDM2 SNP285 Polymorphism with Cancer Susceptibility: A Meta-Analysis
المؤلفون المشاركون
He, Jing
Wang, Ping
Wang, Meilin
Li, Sanqiang
Ma, Lingjun
Xi, Shoumin
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The mouse double minute 2 (MDM2) gene encodes a negative regulator for p53, and the polymorphism SNP285 in the promoter region of MDM2 gene has been implicated in cancer risk, but individual published studies had inconclusive results.
Therefore, we performed this meta-analysis to obtain a more precise estimation between MDM2 SNP285 polymorphism and risk of cancer.
A systematic literature search was performed using the PubMed, Embase, and Chinese Biomedical (CBM) databases.
Ultimately, 16 published studies comprising 14,573 cases and 9,115 controls were included.
Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of associations.
Overall, MDM2 SNP285 polymorphism was significantly associated with a decreased overall cancer risk with the heterozygous model (OR = 0.89, 95% CI = 0.79–0.99), and reduced ORs were observed with other genetic models (dominant: OR = 0.90, 95% CI = 0.79–1.01 and allele comparison: OR = 0.91, 95% CI = 0.80–1.03) but not reaching statistical significance.
Stratification analysis indicated a decreased risk for ovarian cancer, Caucasians, and studies with relatively large sample size.
Despite some limitations, this meta-analysis indicated that the MDM2 SNP285 polymorphism was associated with a decreased cancer risk, which warrants further validation in large and well-designed studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ping& Wang, Meilin& Li, Sanqiang& Ma, Lingjun& Xi, Shoumin& He, Jing. 2016. Association of the MDM2 SNP285 Polymorphism with Cancer Susceptibility: A Meta-Analysis. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103708
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ping…[et al.]. Association of the MDM2 SNP285 Polymorphism with Cancer Susceptibility: A Meta-Analysis. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103708
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ping& Wang, Meilin& Li, Sanqiang& Ma, Lingjun& Xi, Shoumin& He, Jing. Association of the MDM2 SNP285 Polymorphism with Cancer Susceptibility: A Meta-Analysis. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103708
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103708
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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