![](/images/graphics-bg.png)
Association of the MDM2 SNP285 Polymorphism with Cancer Susceptibility: A Meta-Analysis
Joint Authors
He, Jing
Wang, Ping
Wang, Meilin
Li, Sanqiang
Ma, Lingjun
Xi, Shoumin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The mouse double minute 2 (MDM2) gene encodes a negative regulator for p53, and the polymorphism SNP285 in the promoter region of MDM2 gene has been implicated in cancer risk, but individual published studies had inconclusive results.
Therefore, we performed this meta-analysis to obtain a more precise estimation between MDM2 SNP285 polymorphism and risk of cancer.
A systematic literature search was performed using the PubMed, Embase, and Chinese Biomedical (CBM) databases.
Ultimately, 16 published studies comprising 14,573 cases and 9,115 controls were included.
Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of associations.
Overall, MDM2 SNP285 polymorphism was significantly associated with a decreased overall cancer risk with the heterozygous model (OR = 0.89, 95% CI = 0.79–0.99), and reduced ORs were observed with other genetic models (dominant: OR = 0.90, 95% CI = 0.79–1.01 and allele comparison: OR = 0.91, 95% CI = 0.80–1.03) but not reaching statistical significance.
Stratification analysis indicated a decreased risk for ovarian cancer, Caucasians, and studies with relatively large sample size.
Despite some limitations, this meta-analysis indicated that the MDM2 SNP285 polymorphism was associated with a decreased cancer risk, which warrants further validation in large and well-designed studies.
American Psychological Association (APA)
Wang, Ping& Wang, Meilin& Li, Sanqiang& Ma, Lingjun& Xi, Shoumin& He, Jing. 2016. Association of the MDM2 SNP285 Polymorphism with Cancer Susceptibility: A Meta-Analysis. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103708
Modern Language Association (MLA)
Wang, Ping…[et al.]. Association of the MDM2 SNP285 Polymorphism with Cancer Susceptibility: A Meta-Analysis. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103708
American Medical Association (AMA)
Wang, Ping& Wang, Meilin& Li, Sanqiang& Ma, Lingjun& Xi, Shoumin& He, Jing. Association of the MDM2 SNP285 Polymorphism with Cancer Susceptibility: A Meta-Analysis. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103708