TP53 Mutations and Survival in Osteosarcoma Patients: A Meta-Analysis of Published Data
المؤلفون المشاركون
Chen, Zhe
Guo, Jiayi
Zhang, Kun
Guo, Yanxing
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-27
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Several research groups have examined the association between TP53 mutations and prognosis in human osteosarcoma.
However, the results were controversial.
The purpose of this study was to evaluate the prognostic value of TP53 mutations in osteosarcoma patients.
A meta-analysis was conducted with all eligible studies which quantitatively evaluated the relationship between TP53 mutations and clinical outcome of osteosarcoma patients.
Eight studies with a total of 210 patients with osteosarcoma were included in this meta-analysis.
The risk ratio (RR) with a 95% confidence interval (95% CI) was calculated to assess the effect of TP53 mutations on 2-year overall survival.
The quantitative synthesis of 8 published studies showed that TP53 mutations were associated with 2-year overall survival in osteosarcoma patients.
These data suggested that TP53 mutations had an unfavorable impact on 2-year overall survival when compared to the counterparts with wild type (WT) TP53 (RR: 1.79; 95% CI: 1.12 to 2.84; P = 0.01 ; I 2 = 0 %).
There was no between-study heterogeneity.
TP53 mutations are an effective prognostic marker for survival of patients with osteosarcoma.
However, further large-scale prospective trials should be performed to clarify the prognostic value of TP53 mutations on 3- or 5-year survival in osteosarcoma patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Zhe& Guo, Jiayi& Zhang, Kun& Guo, Yanxing. 2016. TP53 Mutations and Survival in Osteosarcoma Patients: A Meta-Analysis of Published Data. Disease Markers،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1103710
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Zhe…[et al.]. TP53 Mutations and Survival in Osteosarcoma Patients: A Meta-Analysis of Published Data. Disease Markers No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1103710
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Zhe& Guo, Jiayi& Zhang, Kun& Guo, Yanxing. TP53 Mutations and Survival in Osteosarcoma Patients: A Meta-Analysis of Published Data. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1103710
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103710
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر