TP53 Mutations and Survival in Osteosarcoma Patients: A Meta-Analysis of Published Data
Joint Authors
Chen, Zhe
Guo, Jiayi
Zhang, Kun
Guo, Yanxing
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Several research groups have examined the association between TP53 mutations and prognosis in human osteosarcoma.
However, the results were controversial.
The purpose of this study was to evaluate the prognostic value of TP53 mutations in osteosarcoma patients.
A meta-analysis was conducted with all eligible studies which quantitatively evaluated the relationship between TP53 mutations and clinical outcome of osteosarcoma patients.
Eight studies with a total of 210 patients with osteosarcoma were included in this meta-analysis.
The risk ratio (RR) with a 95% confidence interval (95% CI) was calculated to assess the effect of TP53 mutations on 2-year overall survival.
The quantitative synthesis of 8 published studies showed that TP53 mutations were associated with 2-year overall survival in osteosarcoma patients.
These data suggested that TP53 mutations had an unfavorable impact on 2-year overall survival when compared to the counterparts with wild type (WT) TP53 (RR: 1.79; 95% CI: 1.12 to 2.84; P = 0.01 ; I 2 = 0 %).
There was no between-study heterogeneity.
TP53 mutations are an effective prognostic marker for survival of patients with osteosarcoma.
However, further large-scale prospective trials should be performed to clarify the prognostic value of TP53 mutations on 3- or 5-year survival in osteosarcoma patients.
American Psychological Association (APA)
Chen, Zhe& Guo, Jiayi& Zhang, Kun& Guo, Yanxing. 2016. TP53 Mutations and Survival in Osteosarcoma Patients: A Meta-Analysis of Published Data. Disease Markers،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1103710
Modern Language Association (MLA)
Chen, Zhe…[et al.]. TP53 Mutations and Survival in Osteosarcoma Patients: A Meta-Analysis of Published Data. Disease Markers No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1103710
American Medical Association (AMA)
Chen, Zhe& Guo, Jiayi& Zhang, Kun& Guo, Yanxing. TP53 Mutations and Survival in Osteosarcoma Patients: A Meta-Analysis of Published Data. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1103710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103710