High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1
المؤلفون المشاركون
Kowalewska, Beata
Szmigiero-Kawko, Małgorzata
Wąż, Piotr
Myśliwiec, Małgorzata
Zorena, Katarzyna
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-29
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The objective of the research was to investigate serum levels of interleukin-12 (IL12) in relation to percentage of yeast-like fungi colonies residing in the gastrointestinal tract in children and adolescents with type 1 diabetes mellitus (T1DM).
The study involved 83 children and adolescents, including 53 T1DM patients and 30 healthy control subjects.
In the studied population biochemical tests were performed and yeast-like fungi were identified in the faeces.
Moreover, IL12 absorbance was measured and measurements of Candida albicans IgG and IgM antibodies were performed with microplate reader ChroMate 4300 (Awareness Technology, Inc., USA) at wavelength λ=450 nm.
In the group of T1DM children and adolescents with disease duration ≤ 2 years, high levels of IL12 were found with lower percentage of yeast-like fungal colonies versus T1DM patients with disease duration > 2 years and ≤5 years, as well as versus T1DM patients with disease duration > 5 years.
Additionally, serum levels of IL12 were found to be decreasing by 18.1 pg/ml with each year of diabetes duration.
IL12 serum levels were also found to be decreasing by 52.9 pg/ml with each 1% increase in HbA1c.
We suggest that high IL12 levels can inhibit infection with yeast-like fungi colonizing the gastrointestinal tract in children and adolescents with T1DM.
Further studies are needed to confirm the antifungal activity of IL12.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kowalewska, Beata& Zorena, Katarzyna& Szmigiero-Kawko, Małgorzata& Wąż, Piotr& Myśliwiec, Małgorzata. 2016. High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1. Disease Markers،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103711
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kowalewska, Beata…[et al.]. High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1. Disease Markers No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103711
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kowalewska, Beata& Zorena, Katarzyna& Szmigiero-Kawko, Małgorzata& Wąż, Piotr& Myśliwiec, Małgorzata. High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103711
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103711
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر