![](/images/graphics-bg.png)
High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1
Joint Authors
Kowalewska, Beata
Szmigiero-Kawko, Małgorzata
Wąż, Piotr
Myśliwiec, Małgorzata
Zorena, Katarzyna
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The objective of the research was to investigate serum levels of interleukin-12 (IL12) in relation to percentage of yeast-like fungi colonies residing in the gastrointestinal tract in children and adolescents with type 1 diabetes mellitus (T1DM).
The study involved 83 children and adolescents, including 53 T1DM patients and 30 healthy control subjects.
In the studied population biochemical tests were performed and yeast-like fungi were identified in the faeces.
Moreover, IL12 absorbance was measured and measurements of Candida albicans IgG and IgM antibodies were performed with microplate reader ChroMate 4300 (Awareness Technology, Inc., USA) at wavelength λ=450 nm.
In the group of T1DM children and adolescents with disease duration ≤ 2 years, high levels of IL12 were found with lower percentage of yeast-like fungal colonies versus T1DM patients with disease duration > 2 years and ≤5 years, as well as versus T1DM patients with disease duration > 5 years.
Additionally, serum levels of IL12 were found to be decreasing by 18.1 pg/ml with each year of diabetes duration.
IL12 serum levels were also found to be decreasing by 52.9 pg/ml with each 1% increase in HbA1c.
We suggest that high IL12 levels can inhibit infection with yeast-like fungi colonizing the gastrointestinal tract in children and adolescents with T1DM.
Further studies are needed to confirm the antifungal activity of IL12.
American Psychological Association (APA)
Kowalewska, Beata& Zorena, Katarzyna& Szmigiero-Kawko, Małgorzata& Wąż, Piotr& Myśliwiec, Małgorzata. 2016. High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1. Disease Markers،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103711
Modern Language Association (MLA)
Kowalewska, Beata…[et al.]. High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1. Disease Markers No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103711
American Medical Association (AMA)
Kowalewska, Beata& Zorena, Katarzyna& Szmigiero-Kawko, Małgorzata& Wąż, Piotr& Myśliwiec, Małgorzata. High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103711