Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up
المؤلفون المشاركون
Shibata, Yoko
Kato, Takeo
Arimoto, Takanori
Shishido, Tetsuro
Yokoyama, Miyuki
Otaki, Yoichiro
Daimon, Makoto
Ueno, Yoshiyuki
Takahashi, Hiroki
Miyamoto, Takuya
Kubota, Isao
Konta, Tsuneo
Watanabe, Tetsu
Kayama, Takamasa
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need.
Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT).
However, the association of AST/ALT ratio with brain natriuretic peptide (BNP) levels and cardiovascular mortality remains unclear in the general population.
Methods and Results.
This longitudinal cohort study included 3,494 Japanese subjects who participated in a community-based health check-up, with a 10-year follow-up.
The AST/ALT ratio increased with increasing BNP levels.
And multivariate logistic analysis showed that the AST/ALT ratio was significantly associated with a high BNP (≥100 pg/mL).
There were 250 all-cause deaths including 79 cardiovascular deaths.
Multivariate Cox proportional hazard regression analysis revealed that a high AST/ALT ratio (>90 percentile) was an independent predictor of all-cause and cardiovascular mortality after adjustment for confounding factors.
Kaplan-Meier analysis demonstrated that cardiovascular mortality was higher in subjects with a high AST/ALT ratio than in those without.
Conclusions.
The AST/ALT ratio was associated with an increase in BNP and was predictive of cardiovascular mortality in a general population.
Measuring the AST/ALT ratio during routine health check-ups may be a simple and cost-effective marker for cardiovascular mortality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yokoyama, Miyuki& Watanabe, Tetsu& Otaki, Yoichiro& Takahashi, Hiroki& Arimoto, Takanori& Shishido, Tetsuro…[et al.]. 2016. Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103715
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yokoyama, Miyuki…[et al.]. Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103715
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yokoyama, Miyuki& Watanabe, Tetsu& Otaki, Yoichiro& Takahashi, Hiroki& Arimoto, Takanori& Shishido, Tetsuro…[et al.]. Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103715
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103715
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر