![](/images/graphics-bg.png)
Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up
Joint Authors
Shibata, Yoko
Kato, Takeo
Arimoto, Takanori
Shishido, Tetsuro
Yokoyama, Miyuki
Otaki, Yoichiro
Daimon, Makoto
Ueno, Yoshiyuki
Takahashi, Hiroki
Miyamoto, Takuya
Kubota, Isao
Konta, Tsuneo
Watanabe, Tetsu
Kayama, Takamasa
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need.
Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT).
However, the association of AST/ALT ratio with brain natriuretic peptide (BNP) levels and cardiovascular mortality remains unclear in the general population.
Methods and Results.
This longitudinal cohort study included 3,494 Japanese subjects who participated in a community-based health check-up, with a 10-year follow-up.
The AST/ALT ratio increased with increasing BNP levels.
And multivariate logistic analysis showed that the AST/ALT ratio was significantly associated with a high BNP (≥100 pg/mL).
There were 250 all-cause deaths including 79 cardiovascular deaths.
Multivariate Cox proportional hazard regression analysis revealed that a high AST/ALT ratio (>90 percentile) was an independent predictor of all-cause and cardiovascular mortality after adjustment for confounding factors.
Kaplan-Meier analysis demonstrated that cardiovascular mortality was higher in subjects with a high AST/ALT ratio than in those without.
Conclusions.
The AST/ALT ratio was associated with an increase in BNP and was predictive of cardiovascular mortality in a general population.
Measuring the AST/ALT ratio during routine health check-ups may be a simple and cost-effective marker for cardiovascular mortality.
American Psychological Association (APA)
Yokoyama, Miyuki& Watanabe, Tetsu& Otaki, Yoichiro& Takahashi, Hiroki& Arimoto, Takanori& Shishido, Tetsuro…[et al.]. 2016. Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103715
Modern Language Association (MLA)
Yokoyama, Miyuki…[et al.]. Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103715
American Medical Association (AMA)
Yokoyama, Miyuki& Watanabe, Tetsu& Otaki, Yoichiro& Takahashi, Hiroki& Arimoto, Takanori& Shishido, Tetsuro…[et al.]. Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103715
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103715