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A Significant Statistical Advancement on the Predictive Values of ERCC1 Polymorphisms for Clinical Outcomes of Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer: An Updated Meta-Analysis
المؤلفون المشاركون
Han, Yali
Sun, Yuping
Liu, Jie
Sun, Meili
Zhang, Zongpu
Liu, Chuanyong
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-21
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
There is no definitive conclusion so far on the predictive values of ERCC1 polymorphisms for clinical outcomes of platinum-based chemotherapy in non-small cell lung cancer (NSCLC).
We updated this meta-analysis with an expectation to obtain some statistical advancement on this issue.
Methods.
Relevant studies were identified by searching MEDLINE, EMBASE databases from inception to April 2015.
Primary outcomes included objective response rate (ORR), progression-free survival (PFS), and overall survival (OS).
All analyses were performed using the Review Manager version 5.3 and the Stata version 12.0.
Results.
A total of 33 studies including 5373 patients were identified.
ERCC1 C118T and C8092A could predict both ORR and OS for platinum-based chemotherapy in Asian NSCLC patients (CT + TT versus CC, ORR: OR = 0.80, 95% CI = 0.67–0.94; OS: HR = 1.24, 95% CI = 1.01–1.53) (CA + AA versus CC, ORR: OR = 0.76, 95% CI = 0.60–0.96; OS: HR = 1.37, 95% CI = 1.06–1.75).
Conclusions.
Current evidence strongly indicated the prospect of ERCC1 C118T and C8092A as predictive biomarkers for platinum-based chemotherapy in Asian NSCLC patients.
However, the results should be interpreted with caution and large prospective studies are still required to further investigate these findings.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Yali& Liu, Jie& Sun, Meili& Zhang, Zongpu& Liu, Chuanyong& Sun, Yuping. 2016. A Significant Statistical Advancement on the Predictive Values of ERCC1 Polymorphisms for Clinical Outcomes of Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer: An Updated Meta-Analysis. Disease Markers،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1103768
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Yali…[et al.]. A Significant Statistical Advancement on the Predictive Values of ERCC1 Polymorphisms for Clinical Outcomes of Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer: An Updated Meta-Analysis. Disease Markers No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1103768
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Yali& Liu, Jie& Sun, Meili& Zhang, Zongpu& Liu, Chuanyong& Sun, Yuping. A Significant Statistical Advancement on the Predictive Values of ERCC1 Polymorphisms for Clinical Outcomes of Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer: An Updated Meta-Analysis. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1103768
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103768
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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