A Significant Statistical Advancement on the Predictive Values of ERCC1 Polymorphisms for Clinical Outcomes of Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer: An Updated Meta-Analysis
Joint Authors
Han, Yali
Sun, Yuping
Liu, Jie
Sun, Meili
Zhang, Zongpu
Liu, Chuanyong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
There is no definitive conclusion so far on the predictive values of ERCC1 polymorphisms for clinical outcomes of platinum-based chemotherapy in non-small cell lung cancer (NSCLC).
We updated this meta-analysis with an expectation to obtain some statistical advancement on this issue.
Methods.
Relevant studies were identified by searching MEDLINE, EMBASE databases from inception to April 2015.
Primary outcomes included objective response rate (ORR), progression-free survival (PFS), and overall survival (OS).
All analyses were performed using the Review Manager version 5.3 and the Stata version 12.0.
Results.
A total of 33 studies including 5373 patients were identified.
ERCC1 C118T and C8092A could predict both ORR and OS for platinum-based chemotherapy in Asian NSCLC patients (CT + TT versus CC, ORR: OR = 0.80, 95% CI = 0.67–0.94; OS: HR = 1.24, 95% CI = 1.01–1.53) (CA + AA versus CC, ORR: OR = 0.76, 95% CI = 0.60–0.96; OS: HR = 1.37, 95% CI = 1.06–1.75).
Conclusions.
Current evidence strongly indicated the prospect of ERCC1 C118T and C8092A as predictive biomarkers for platinum-based chemotherapy in Asian NSCLC patients.
However, the results should be interpreted with caution and large prospective studies are still required to further investigate these findings.
American Psychological Association (APA)
Han, Yali& Liu, Jie& Sun, Meili& Zhang, Zongpu& Liu, Chuanyong& Sun, Yuping. 2016. A Significant Statistical Advancement on the Predictive Values of ERCC1 Polymorphisms for Clinical Outcomes of Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer: An Updated Meta-Analysis. Disease Markers،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1103768
Modern Language Association (MLA)
Han, Yali…[et al.]. A Significant Statistical Advancement on the Predictive Values of ERCC1 Polymorphisms for Clinical Outcomes of Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer: An Updated Meta-Analysis. Disease Markers No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1103768
American Medical Association (AMA)
Han, Yali& Liu, Jie& Sun, Meili& Zhang, Zongpu& Liu, Chuanyong& Sun, Yuping. A Significant Statistical Advancement on the Predictive Values of ERCC1 Polymorphisms for Clinical Outcomes of Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer: An Updated Meta-Analysis. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1103768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103768