Increased Serum Level of MicroRNA-663 Is Correlated with Poor Prognosis of Patients with Nasopharyngeal Carcinoma
المؤلفون المشاركون
Liang, Shaoqiang
Zhang, Ning
Deng, Yanming
Chen, Lusi
Zhang, Yang
Zheng, Zhenhe
Luo, Weijun
Lv, Zhiqian
Li, Shaoen
Xun, Tao
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-07
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
MicroRNAs (miRs) play crucial roles in the carcinogenesis and malignant progression of human cancers including nasopharyngeal carcinoma (NPC).
In this study, we aimed to investigate the association of serum miR-663 levels with the clinical factors and prognosis of NPC patients.
Real-time PCR was performed to examine the amount of miR-663 in serum in NPC patients and healthy controls.
Our data showed that the amount of miR-663 in serum was significantly higher in NPC patients than in healthy controls.
Moreover, the serum levels of miR-663 were significantly correlated with the grade, lymph node metastasis, and clinical stage of NPC.
Furthermore, higher serum miR-663 levels were closely associated with worse 5-year overall survival (OS) and relapse-free survival (RFS) of patients with NPC, and the serum level of miR-663 was found to be an independent predicator for the prognosis of NPC.
In addition, after receiving chemoradiotherapy, the serum levels of miR-663 were significantly reduced in NPC patients.
In summary, miR-663 was upregulated in the serum of NPC patients, which was downregulated after chemoradiotherapy, and its increased levels were closely associated with malignant progression and poor prognosis in NPC patients.
Therefore, the amount of miR-663 in serum may become a potential predicator for the clinical outcome of NPC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liang, Shaoqiang& Zhang, Ning& Deng, Yanming& Chen, Lusi& Zhang, Yang& Zheng, Zhenhe…[et al.]. 2016. Increased Serum Level of MicroRNA-663 Is Correlated with Poor Prognosis of Patients with Nasopharyngeal Carcinoma. Disease Markers،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103769
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liang, Shaoqiang…[et al.]. Increased Serum Level of MicroRNA-663 Is Correlated with Poor Prognosis of Patients with Nasopharyngeal Carcinoma. Disease Markers No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103769
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liang, Shaoqiang& Zhang, Ning& Deng, Yanming& Chen, Lusi& Zhang, Yang& Zheng, Zhenhe…[et al.]. Increased Serum Level of MicroRNA-663 Is Correlated with Poor Prognosis of Patients with Nasopharyngeal Carcinoma. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103769
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103769
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر