Increased Serum Level of MicroRNA-663 Is Correlated with Poor Prognosis of Patients with Nasopharyngeal Carcinoma
Joint Authors
Liang, Shaoqiang
Zhang, Ning
Deng, Yanming
Chen, Lusi
Zhang, Yang
Zheng, Zhenhe
Luo, Weijun
Lv, Zhiqian
Li, Shaoen
Xun, Tao
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
MicroRNAs (miRs) play crucial roles in the carcinogenesis and malignant progression of human cancers including nasopharyngeal carcinoma (NPC).
In this study, we aimed to investigate the association of serum miR-663 levels with the clinical factors and prognosis of NPC patients.
Real-time PCR was performed to examine the amount of miR-663 in serum in NPC patients and healthy controls.
Our data showed that the amount of miR-663 in serum was significantly higher in NPC patients than in healthy controls.
Moreover, the serum levels of miR-663 were significantly correlated with the grade, lymph node metastasis, and clinical stage of NPC.
Furthermore, higher serum miR-663 levels were closely associated with worse 5-year overall survival (OS) and relapse-free survival (RFS) of patients with NPC, and the serum level of miR-663 was found to be an independent predicator for the prognosis of NPC.
In addition, after receiving chemoradiotherapy, the serum levels of miR-663 were significantly reduced in NPC patients.
In summary, miR-663 was upregulated in the serum of NPC patients, which was downregulated after chemoradiotherapy, and its increased levels were closely associated with malignant progression and poor prognosis in NPC patients.
Therefore, the amount of miR-663 in serum may become a potential predicator for the clinical outcome of NPC patients.
American Psychological Association (APA)
Liang, Shaoqiang& Zhang, Ning& Deng, Yanming& Chen, Lusi& Zhang, Yang& Zheng, Zhenhe…[et al.]. 2016. Increased Serum Level of MicroRNA-663 Is Correlated with Poor Prognosis of Patients with Nasopharyngeal Carcinoma. Disease Markers،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103769
Modern Language Association (MLA)
Liang, Shaoqiang…[et al.]. Increased Serum Level of MicroRNA-663 Is Correlated with Poor Prognosis of Patients with Nasopharyngeal Carcinoma. Disease Markers No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103769
American Medical Association (AMA)
Liang, Shaoqiang& Zhang, Ning& Deng, Yanming& Chen, Lusi& Zhang, Yang& Zheng, Zhenhe…[et al.]. Increased Serum Level of MicroRNA-663 Is Correlated with Poor Prognosis of Patients with Nasopharyngeal Carcinoma. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103769
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103769