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The Ratio of Hmox1Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer
المؤلفون المشاركون
Chang, Liang-Che
Fan, Chung-Wei
Tseng, Wen-Ko
Chein, Hui-Ping
Hsieh, Tsan-Yu
Chen, Jim-Ray
Hwang, Cheng-Cheng
Hua, Chung-Ching
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-23
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Heme oxygenase 1 (Hmox1) plays an important role in the growth and spread of tumor, and its expression is regulated positively by Nrf2 [nuclear factor (erythroid-derived 2)-like 2; NFE2L2] and negatively by kelch-like ECH-associated protein 1 (Keap1) and by BTB and CNC homology 1 (Bach1).
Both Hmox1 and Nrf2 contribute to distant metastasis of cancer.
The mRNA levels of Hmox1, Nrf2, Keap1, and Bach1 in the tumor and normal tissues of 84 subjects with colorectal cancer (CRC) were determined by real-time polymerase chain reaction.
The tumor had lower Hmox1 but higher Bach1 mRNA levels than the normal tissue.
The correlations of Hmox1 with components of the Nrf2 pathway were not significant in the tumor tissue of CRC subjects with distant metastasis.
The ratio of Hmox1/Nrf2 mRNA level (by percentage) in the tumor tissue was lower in the subjects with distant metastasis (97.4% (84.4–111.1%)) than in those without (101.0% (92.7–136.5%)) and was a predictor for distant metastasis in CRC (odds ratio: 0.83; 95% confidence interval: 0.68–0.97) along with serum carcinoembryonic antigen (1.0027, 1.006–1.064).
The mRNA level of Hmox1 in the tumor tissue of CRC is not correlated with that of the Nrf2 pathway molecules, and its ratio to the Nrf2 level may be useful for suggesting distant metastasis in CRC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Liang-Che& Fan, Chung-Wei& Tseng, Wen-Ko& Chein, Hui-Ping& Hsieh, Tsan-Yu& Chen, Jim-Ray…[et al.]. 2016. The Ratio of Hmox1Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer. Disease Markers،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103781
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Liang-Che…[et al.]. The Ratio of Hmox1Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer. Disease Markers No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103781
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Liang-Che& Fan, Chung-Wei& Tseng, Wen-Ko& Chein, Hui-Ping& Hsieh, Tsan-Yu& Chen, Jim-Ray…[et al.]. The Ratio of Hmox1Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103781
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103781
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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