The Ratio of Hmox1Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer
Joint Authors
Chang, Liang-Che
Fan, Chung-Wei
Tseng, Wen-Ko
Chein, Hui-Ping
Hsieh, Tsan-Yu
Chen, Jim-Ray
Hwang, Cheng-Cheng
Hua, Chung-Ching
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Heme oxygenase 1 (Hmox1) plays an important role in the growth and spread of tumor, and its expression is regulated positively by Nrf2 [nuclear factor (erythroid-derived 2)-like 2; NFE2L2] and negatively by kelch-like ECH-associated protein 1 (Keap1) and by BTB and CNC homology 1 (Bach1).
Both Hmox1 and Nrf2 contribute to distant metastasis of cancer.
The mRNA levels of Hmox1, Nrf2, Keap1, and Bach1 in the tumor and normal tissues of 84 subjects with colorectal cancer (CRC) were determined by real-time polymerase chain reaction.
The tumor had lower Hmox1 but higher Bach1 mRNA levels than the normal tissue.
The correlations of Hmox1 with components of the Nrf2 pathway were not significant in the tumor tissue of CRC subjects with distant metastasis.
The ratio of Hmox1/Nrf2 mRNA level (by percentage) in the tumor tissue was lower in the subjects with distant metastasis (97.4% (84.4–111.1%)) than in those without (101.0% (92.7–136.5%)) and was a predictor for distant metastasis in CRC (odds ratio: 0.83; 95% confidence interval: 0.68–0.97) along with serum carcinoembryonic antigen (1.0027, 1.006–1.064).
The mRNA level of Hmox1 in the tumor tissue of CRC is not correlated with that of the Nrf2 pathway molecules, and its ratio to the Nrf2 level may be useful for suggesting distant metastasis in CRC.
American Psychological Association (APA)
Chang, Liang-Che& Fan, Chung-Wei& Tseng, Wen-Ko& Chein, Hui-Ping& Hsieh, Tsan-Yu& Chen, Jim-Ray…[et al.]. 2016. The Ratio of Hmox1Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer. Disease Markers،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103781
Modern Language Association (MLA)
Chang, Liang-Che…[et al.]. The Ratio of Hmox1Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer. Disease Markers No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103781
American Medical Association (AMA)
Chang, Liang-Che& Fan, Chung-Wei& Tseng, Wen-Ko& Chein, Hui-Ping& Hsieh, Tsan-Yu& Chen, Jim-Ray…[et al.]. The Ratio of Hmox1Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103781