Insulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification
المؤلفون المشاركون
Vargas-Alarcón, Gilberto
Juárez, Juan Gabriel
Cardoso-Saldaña, Guillermo C.
Jorge-Galarza, Esteban
Torres-Tamayo, Margarita
Medina-Urrutia, Aida X.
Rodas-Díaz, Marco A.
Posadas-Sánchez, Rosalinda
González-Salazar, María del Carmen
Posadas-Romero, Carlos
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Insulin resistance is involved in the pathogenesis of cardiovascular disease, but its relationship with cardiovascular calcification has yielded conflicting results.
The purpose of the present study was to investigate the role of hepatic and adipose tissue insulin resistance on the presence of coronary artery (CAC > 0) and aortic valve calcification (AVC > 0).
Methods.
In 1201 subjects (52% women, 53.6±9.3 years old) without familiar and personal history of coronary heart disease, CAC and AVC were assessed by multidetector-computed tomography.
Cardiovascular risk factors were documented and lipid profile, inflammation markers, glucose, insulin, and free fatty acids were measured.
Hepatic insulin resistance (HOMA-IR) and adipose tissue insulin resistance (Adipo-IR) indices were calculated.
Results.
There was a significant relationship between HOMA-IR and Adipo-IR indices (r=0.758, p<0.001).
Participants in the highest quartiles of HOMA-IR and Adipo-IR indices had a more adverse cardiovascular profile and higher prevalence of CAC > 0 and AVC > 0.
After full adjustment, subjects in the highest quartile of Adipo-IR index had higher odds of AVC > 0 (OR: 2.40; 95% CI: 1.30–4.43), as compared to those in the lowest quartile.
Conclusions.
Adipo-IR was independently associated with AVC > 0.
This suggests that abnormal adipose tissue function favors insulin resistance that may promote the development and progression of AVC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jorge-Galarza, Esteban& Posadas-Romero, Carlos& Torres-Tamayo, Margarita& Medina-Urrutia, Aida X.& Rodas-Díaz, Marco A.& Posadas-Sánchez, Rosalinda…[et al.]. 2016. Insulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103802
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jorge-Galarza, Esteban…[et al.]. Insulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103802
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jorge-Galarza, Esteban& Posadas-Romero, Carlos& Torres-Tamayo, Margarita& Medina-Urrutia, Aida X.& Rodas-Díaz, Marco A.& Posadas-Sánchez, Rosalinda…[et al.]. Insulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103802
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103802
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر