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Insulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification
Joint Authors
Vargas-Alarcón, Gilberto
Juárez, Juan Gabriel
Cardoso-Saldaña, Guillermo C.
Jorge-Galarza, Esteban
Torres-Tamayo, Margarita
Medina-Urrutia, Aida X.
Rodas-Díaz, Marco A.
Posadas-Sánchez, Rosalinda
González-Salazar, María del Carmen
Posadas-Romero, Carlos
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Insulin resistance is involved in the pathogenesis of cardiovascular disease, but its relationship with cardiovascular calcification has yielded conflicting results.
The purpose of the present study was to investigate the role of hepatic and adipose tissue insulin resistance on the presence of coronary artery (CAC > 0) and aortic valve calcification (AVC > 0).
Methods.
In 1201 subjects (52% women, 53.6±9.3 years old) without familiar and personal history of coronary heart disease, CAC and AVC were assessed by multidetector-computed tomography.
Cardiovascular risk factors were documented and lipid profile, inflammation markers, glucose, insulin, and free fatty acids were measured.
Hepatic insulin resistance (HOMA-IR) and adipose tissue insulin resistance (Adipo-IR) indices were calculated.
Results.
There was a significant relationship between HOMA-IR and Adipo-IR indices (r=0.758, p<0.001).
Participants in the highest quartiles of HOMA-IR and Adipo-IR indices had a more adverse cardiovascular profile and higher prevalence of CAC > 0 and AVC > 0.
After full adjustment, subjects in the highest quartile of Adipo-IR index had higher odds of AVC > 0 (OR: 2.40; 95% CI: 1.30–4.43), as compared to those in the lowest quartile.
Conclusions.
Adipo-IR was independently associated with AVC > 0.
This suggests that abnormal adipose tissue function favors insulin resistance that may promote the development and progression of AVC.
American Psychological Association (APA)
Jorge-Galarza, Esteban& Posadas-Romero, Carlos& Torres-Tamayo, Margarita& Medina-Urrutia, Aida X.& Rodas-Díaz, Marco A.& Posadas-Sánchez, Rosalinda…[et al.]. 2016. Insulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103802
Modern Language Association (MLA)
Jorge-Galarza, Esteban…[et al.]. Insulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103802
American Medical Association (AMA)
Jorge-Galarza, Esteban& Posadas-Romero, Carlos& Torres-Tamayo, Margarita& Medina-Urrutia, Aida X.& Rodas-Díaz, Marco A.& Posadas-Sánchez, Rosalinda…[et al.]. Insulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103802