The Effect of Oseltamivir on the Disease Progression of Lethal Influenza A Virus Infection: Plasma Cytokine and miRNA Responses in a Mouse Model
المؤلفون المشاركون
Boyne II, Michael T.
Chockalingam, Ashok K.
Hamed, Salaheldin
Goodwin, David G.
Rosenzweig, Barry A.
Pang, Eric
Patel, Vikram
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-08
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Lethal influenza A virus infection leads to acute lung injury and possibly lethal complications.
There has been a continuous effort to identify the possible predictors of disease severity.
Unlike earlier studies, where biomarkers were analyzed on certain time points or days after infection, in this study biomarkers were evaluated over the entire course of infection.
Circulating proinflammatory cytokines and/or miRNAs that track with the onset and progression of lethal A/Puerto Rico/8/34 (PR8) influenza A virus infection and their response to oseltamivir treatment were investigated up to 10 days after infection.
Changes in plasma cytokines (IL-1β, IL-10, IL-12p70, IL-6, KC, TNF-α, and IFN-γ) and several candidate miRNAs were profiled.
Among the cytokines analyzed, IL-6 and KC/GRO cytokines appeared to correlate with peak viral titer.
Over the selected 48 miRNAs profiled, certain miRNAs were up- or downregulated in a manner that was dependent on the oseltamivir treatment and disease severity.
Our findings suggest that IL-6 and KC/GRO cytokines can be a potential disease severity biomarker and/or marker for the progression/remission of infection.
Further studies to explore other cytokines, miRNAs, and lung injury proteins in serum with different subtypes of influenza A viruses with varying disease severity may provide new insight into other unique biomarkers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chockalingam, Ashok K.& Hamed, Salaheldin& Goodwin, David G.& Rosenzweig, Barry A.& Pang, Eric& Boyne II, Michael T.…[et al.]. 2016. The Effect of Oseltamivir on the Disease Progression of Lethal Influenza A Virus Infection: Plasma Cytokine and miRNA Responses in a Mouse Model. Disease Markers،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103817
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chockalingam, Ashok K.…[et al.]. The Effect of Oseltamivir on the Disease Progression of Lethal Influenza A Virus Infection: Plasma Cytokine and miRNA Responses in a Mouse Model. Disease Markers No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1103817
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chockalingam, Ashok K.& Hamed, Salaheldin& Goodwin, David G.& Rosenzweig, Barry A.& Pang, Eric& Boyne II, Michael T.…[et al.]. The Effect of Oseltamivir on the Disease Progression of Lethal Influenza A Virus Infection: Plasma Cytokine and miRNA Responses in a Mouse Model. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103817
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103817
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر