The Effect of Oseltamivir on the Disease Progression of Lethal Influenza A Virus Infection: Plasma Cytokine and miRNA Responses in a Mouse Model
Joint Authors
Boyne II, Michael T.
Chockalingam, Ashok K.
Hamed, Salaheldin
Goodwin, David G.
Rosenzweig, Barry A.
Pang, Eric
Patel, Vikram
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Lethal influenza A virus infection leads to acute lung injury and possibly lethal complications.
There has been a continuous effort to identify the possible predictors of disease severity.
Unlike earlier studies, where biomarkers were analyzed on certain time points or days after infection, in this study biomarkers were evaluated over the entire course of infection.
Circulating proinflammatory cytokines and/or miRNAs that track with the onset and progression of lethal A/Puerto Rico/8/34 (PR8) influenza A virus infection and their response to oseltamivir treatment were investigated up to 10 days after infection.
Changes in plasma cytokines (IL-1β, IL-10, IL-12p70, IL-6, KC, TNF-α, and IFN-γ) and several candidate miRNAs were profiled.
Among the cytokines analyzed, IL-6 and KC/GRO cytokines appeared to correlate with peak viral titer.
Over the selected 48 miRNAs profiled, certain miRNAs were up- or downregulated in a manner that was dependent on the oseltamivir treatment and disease severity.
Our findings suggest that IL-6 and KC/GRO cytokines can be a potential disease severity biomarker and/or marker for the progression/remission of infection.
Further studies to explore other cytokines, miRNAs, and lung injury proteins in serum with different subtypes of influenza A viruses with varying disease severity may provide new insight into other unique biomarkers.
American Psychological Association (APA)
Chockalingam, Ashok K.& Hamed, Salaheldin& Goodwin, David G.& Rosenzweig, Barry A.& Pang, Eric& Boyne II, Michael T.…[et al.]. 2016. The Effect of Oseltamivir on the Disease Progression of Lethal Influenza A Virus Infection: Plasma Cytokine and miRNA Responses in a Mouse Model. Disease Markers،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103817
Modern Language Association (MLA)
Chockalingam, Ashok K.…[et al.]. The Effect of Oseltamivir on the Disease Progression of Lethal Influenza A Virus Infection: Plasma Cytokine and miRNA Responses in a Mouse Model. Disease Markers No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1103817
American Medical Association (AMA)
Chockalingam, Ashok K.& Hamed, Salaheldin& Goodwin, David G.& Rosenzweig, Barry A.& Pang, Eric& Boyne II, Michael T.…[et al.]. The Effect of Oseltamivir on the Disease Progression of Lethal Influenza A Virus Infection: Plasma Cytokine and miRNA Responses in a Mouse Model. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103817