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MUC1 Immunohistochemical Expression as a Prognostic Factor in Gastric Cancer: Meta-Analysis
المؤلفون المشاركون
Wang, Xiao-Tong
Kong, Fan-Biao
Mai, Wei
Li, Lei
Pang, Li-Ming
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
MUC1, a member of the mucin family, is expressed in tumors of various human organs and may function as an antiadhesion molecule that inhibits cell-to-cell adhesion, inducing tumor metastasis, and served as a potential biomarker of tumor progression in early gastric cancer.
However, its prognostic significance in gastric cancer is still in dispute.
We performed a meta-analysis to evaluate the relationship between MUC1 expression and prognosis of gastric cancer.
A total of ten eligible studies with 834 cases and 548 controls were included.
MUC1 positive cases were highly positive in intestinal-type carcinomas (OR = 1.76, 95% CI: 1.27–2.44, P=0.0008 fixed-effect), higher rate of vascular invasion (OR = 1.64, 95% CI: 1.13–2.39, P=0.009 fixed-effect), and lymph node metastasis (OR = 2.10, 95% CI: 1.20–3.67, P=0.01 random-effect), as well as lower 5-year survival rate (HR = 0.27, 95% CI: 0.11–0.66, P=0.004 random-effect).
However, the presence of MUC1 was not associated with gender, tumor size, histologic differentiation, and clinical stage.
In summary, MUC1 is a prognostic factor in gastric cancer, which acts as a marker of poor outcome in patients with gastric cancer.
Further clinical studies are needed to confirm the role of MUC1 in clinical practice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xiao-Tong& Kong, Fan-Biao& Mai, Wei& Li, Lei& Pang, Li-Ming. 2016. MUC1 Immunohistochemical Expression as a Prognostic Factor in Gastric Cancer: Meta-Analysis. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103823
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xiao-Tong…[et al.]. MUC1 Immunohistochemical Expression as a Prognostic Factor in Gastric Cancer: Meta-Analysis. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103823
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xiao-Tong& Kong, Fan-Biao& Mai, Wei& Li, Lei& Pang, Li-Ming. MUC1 Immunohistochemical Expression as a Prognostic Factor in Gastric Cancer: Meta-Analysis. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103823
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103823
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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