MUC1 Immunohistochemical Expression as a Prognostic Factor in Gastric Cancer: Meta-Analysis

Abstract EN

MUC1, a member of the mucin family, is expressed in tumors of various human organs and may function as an antiadhesion molecule that inhibits cell-to-cell adhesion, inducing tumor metastasis, and served as a potential biomarker of tumor progression in early gastric cancer.

However, its prognostic significance in gastric cancer is still in dispute.

We performed a meta-analysis to evaluate the relationship between MUC1 expression and prognosis of gastric cancer.

A total of ten eligible studies with 834 cases and 548 controls were included.

MUC1 positive cases were highly positive in intestinal-type carcinomas (OR = 1.76, 95% CI: 1.27–2.44, P=0.0008 fixed-effect), higher rate of vascular invasion (OR = 1.64, 95% CI: 1.13–2.39, P=0.009 fixed-effect), and lymph node metastasis (OR = 2.10, 95% CI: 1.20–3.67, P=0.01 random-effect), as well as lower 5-year survival rate (HR = 0.27, 95% CI: 0.11–0.66, P=0.004 random-effect).

However, the presence of MUC1 was not associated with gender, tumor size, histologic differentiation, and clinical stage.

In summary, MUC1 is a prognostic factor in gastric cancer, which acts as a marker of poor outcome in patients with gastric cancer.

Further clinical studies are needed to confirm the role of MUC1 in clinical practice.