Steamed and Fermented Ethanolic Extract from Codonopsis lanceolata Attenuates Amyloid-β-Induced Memory Impairment in Mice
المؤلفون المشاركون
Ma, Choong Je
Ko, Hyun-Jeong
Eom, Min Rye
Jung, Youn Sik
Hong, Eun-Hye
Weon, Jin Bae
Park, Dong-Sik
Lee, Hyeon Yong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Codonopsis lanceolata (C.
lanceolata) is a traditional medicinal plant used for the treatment of certain inflammatory diseases such as asthma, tonsillitis, and pharyngitis.
We evaluated whether steamed and fermented C.
lanceolata (SFC) extract improves amyloid-β- (Aβ-) induced learning and memory impairment in mice.
The Morris water maze and passive avoidance tests were used to evaluate the effect of SFC extract.
Moreover, we investigated acetylcholinesterase (AChE) activity and brain-derived neurotrophic factor (BDNF), cyclic AMP response element-binding protein (CREB), and extracellular signal-regulated kinase (ERK) signaling in the hippocampus of mice to determine a possible mechanism for the cognitive-enhancing effect.
Saponin compounds in SFC were identified by Ultra Performance Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry (UPLC-Q-TOF-MS).
SFC extract ameliorated amyloid-β-induced memory impairment in the Morris water maze and passive avoidance tests.
SFC extract inhibited AChE activity and also significantly increased the level of CREB phosphorylation, BDNF expression, and ERK activation in hippocampal tissue of amyloid-β-treated mice.
Lancemasides A, B, C, D, E, and G and foetidissimoside A compounds present in SFC were determined by UPLC-Q-TOF-MS.
These results indicate that SFC extract improves Aβ-induced memory deficits and that AChE inhibition and CREB/BDNF/ERK expression is important for the effect of the SFC extract.
In addition, lancemaside A specifically may be responsible for efficacious effect of SFC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Weon, Jin Bae& Eom, Min Rye& Jung, Youn Sik& Hong, Eun-Hye& Ko, Hyun-Jeong& Lee, Hyeon Yong…[et al.]. 2016. Steamed and Fermented Ethanolic Extract from Codonopsis lanceolata Attenuates Amyloid-β-Induced Memory Impairment in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103905
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Weon, Jin Bae…[et al.]. Steamed and Fermented Ethanolic Extract from Codonopsis lanceolata Attenuates Amyloid-β-Induced Memory Impairment in Mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103905
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Weon, Jin Bae& Eom, Min Rye& Jung, Youn Sik& Hong, Eun-Hye& Ko, Hyun-Jeong& Lee, Hyeon Yong…[et al.]. Steamed and Fermented Ethanolic Extract from Codonopsis lanceolata Attenuates Amyloid-β-Induced Memory Impairment in Mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103905
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103905
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر