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Steamed and Fermented Ethanolic Extract from Codonopsis lanceolata Attenuates Amyloid-β-Induced Memory Impairment in Mice
Joint Authors
Ma, Choong Je
Ko, Hyun-Jeong
Eom, Min Rye
Jung, Youn Sik
Hong, Eun-Hye
Weon, Jin Bae
Park, Dong-Sik
Lee, Hyeon Yong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Codonopsis lanceolata (C.
lanceolata) is a traditional medicinal plant used for the treatment of certain inflammatory diseases such as asthma, tonsillitis, and pharyngitis.
We evaluated whether steamed and fermented C.
lanceolata (SFC) extract improves amyloid-β- (Aβ-) induced learning and memory impairment in mice.
The Morris water maze and passive avoidance tests were used to evaluate the effect of SFC extract.
Moreover, we investigated acetylcholinesterase (AChE) activity and brain-derived neurotrophic factor (BDNF), cyclic AMP response element-binding protein (CREB), and extracellular signal-regulated kinase (ERK) signaling in the hippocampus of mice to determine a possible mechanism for the cognitive-enhancing effect.
Saponin compounds in SFC were identified by Ultra Performance Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry (UPLC-Q-TOF-MS).
SFC extract ameliorated amyloid-β-induced memory impairment in the Morris water maze and passive avoidance tests.
SFC extract inhibited AChE activity and also significantly increased the level of CREB phosphorylation, BDNF expression, and ERK activation in hippocampal tissue of amyloid-β-treated mice.
Lancemasides A, B, C, D, E, and G and foetidissimoside A compounds present in SFC were determined by UPLC-Q-TOF-MS.
These results indicate that SFC extract improves Aβ-induced memory deficits and that AChE inhibition and CREB/BDNF/ERK expression is important for the effect of the SFC extract.
In addition, lancemaside A specifically may be responsible for efficacious effect of SFC.
American Psychological Association (APA)
Weon, Jin Bae& Eom, Min Rye& Jung, Youn Sik& Hong, Eun-Hye& Ko, Hyun-Jeong& Lee, Hyeon Yong…[et al.]. 2016. Steamed and Fermented Ethanolic Extract from Codonopsis lanceolata Attenuates Amyloid-β-Induced Memory Impairment in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103905
Modern Language Association (MLA)
Weon, Jin Bae…[et al.]. Steamed and Fermented Ethanolic Extract from Codonopsis lanceolata Attenuates Amyloid-β-Induced Memory Impairment in Mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103905
American Medical Association (AMA)
Weon, Jin Bae& Eom, Min Rye& Jung, Youn Sik& Hong, Eun-Hye& Ko, Hyun-Jeong& Lee, Hyeon Yong…[et al.]. Steamed and Fermented Ethanolic Extract from Codonopsis lanceolata Attenuates Amyloid-β-Induced Memory Impairment in Mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103905