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Sex-Dependent Effects of Dietary Genistein on Echocardiographic Profile and Cardiac GLUT4 Signaling in Mice
المؤلفون المشاركون
Broderick, Tom L.
Leung, Lana
Martin, Joshua B.
Lawmaster, Todd
Arthur, Kathryn
Al-Nakkash, Layla
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
This study aimed to determine whether genistein diet resulted in changes in cardiac function, using echocardiography, and expression of key proteins involved in glucose uptake by the myocardium.
Intact male and female C57BL/6J mice (aged 4–6 weeks) were fed either 600 mg genistein/kg diet (600 G) or 0 mg genistein/kg diet (0 G) for 4 weeks.
Echocardiography data revealed sex-dependent differences in the absence of genistein: compared to females, hearts from males exhibited increased systolic left ventricle internal dimension (LVIDs), producing a decrease in function, expressed as fractional shortening (FS).
Genistein diet also induced echocardiographic changes in function: in female hearts, 600G induced a 1.5-fold ( P < 0.05 ) increase in LVIDs, resulting in a significant decrease in FS and whole heart surface area when compared to controls (fed 0 G).
Genistein diet increased cardiac GLUT4 protein expression in both males (1.51-fold, P < 0.05 ) and females (1.76-fold, P < 0.05 ).
However, no effects on the expression of notable intracellular signaling glucose uptake-regulated proteins were observed.
Our data indicate that consumption of genistein diet for 4 weeks induces echocardiographic changes in indices of systolic function in females and has beneficial effects on cardiac GLUT4 protein expression in both males and females.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leung, Lana& Martin, Joshua B.& Lawmaster, Todd& Arthur, Kathryn& Broderick, Tom L.& Al-Nakkash, Layla. 2016. Sex-Dependent Effects of Dietary Genistein on Echocardiographic Profile and Cardiac GLUT4 Signaling in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103928
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leung, Lana…[et al.]. Sex-Dependent Effects of Dietary Genistein on Echocardiographic Profile and Cardiac GLUT4 Signaling in Mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103928
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leung, Lana& Martin, Joshua B.& Lawmaster, Todd& Arthur, Kathryn& Broderick, Tom L.& Al-Nakkash, Layla. Sex-Dependent Effects of Dietary Genistein on Echocardiographic Profile and Cardiac GLUT4 Signaling in Mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103928
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103928
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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