Sex-Dependent Effects of Dietary Genistein on Echocardiographic Profile and Cardiac GLUT4 Signaling in Mice
Joint Authors
Broderick, Tom L.
Leung, Lana
Martin, Joshua B.
Lawmaster, Todd
Arthur, Kathryn
Al-Nakkash, Layla
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study aimed to determine whether genistein diet resulted in changes in cardiac function, using echocardiography, and expression of key proteins involved in glucose uptake by the myocardium.
Intact male and female C57BL/6J mice (aged 4–6 weeks) were fed either 600 mg genistein/kg diet (600 G) or 0 mg genistein/kg diet (0 G) for 4 weeks.
Echocardiography data revealed sex-dependent differences in the absence of genistein: compared to females, hearts from males exhibited increased systolic left ventricle internal dimension (LVIDs), producing a decrease in function, expressed as fractional shortening (FS).
Genistein diet also induced echocardiographic changes in function: in female hearts, 600G induced a 1.5-fold ( P < 0.05 ) increase in LVIDs, resulting in a significant decrease in FS and whole heart surface area when compared to controls (fed 0 G).
Genistein diet increased cardiac GLUT4 protein expression in both males (1.51-fold, P < 0.05 ) and females (1.76-fold, P < 0.05 ).
However, no effects on the expression of notable intracellular signaling glucose uptake-regulated proteins were observed.
Our data indicate that consumption of genistein diet for 4 weeks induces echocardiographic changes in indices of systolic function in females and has beneficial effects on cardiac GLUT4 protein expression in both males and females.
American Psychological Association (APA)
Leung, Lana& Martin, Joshua B.& Lawmaster, Todd& Arthur, Kathryn& Broderick, Tom L.& Al-Nakkash, Layla. 2016. Sex-Dependent Effects of Dietary Genistein on Echocardiographic Profile and Cardiac GLUT4 Signaling in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103928
Modern Language Association (MLA)
Leung, Lana…[et al.]. Sex-Dependent Effects of Dietary Genistein on Echocardiographic Profile and Cardiac GLUT4 Signaling in Mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103928
American Medical Association (AMA)
Leung, Lana& Martin, Joshua B.& Lawmaster, Todd& Arthur, Kathryn& Broderick, Tom L.& Al-Nakkash, Layla. Sex-Dependent Effects of Dietary Genistein on Echocardiographic Profile and Cardiac GLUT4 Signaling in Mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103928
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103928